AJP - GI Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 280: G1289-G1295, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kono, H.
Right arrow Articles by Thurman, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kono, H.
Right arrow Articles by Thurman, R. G.
Vol. 280, Issue 6, G1289-G1295, June 2001

ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice

Hiroshi Kono, Takehiko Uesugi, Matthias Froh, Ivan Rusyn, Blair U. Bradford, and Ronald G. Thurman

Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599-7365

To test the hypothesis that leukocyte infiltration mediated by intercellular adhesion molecule (ICAM)-1 is involved in early alcohol-induced liver injury, male wild-type or ICAM-1 knockout mice were fed a high-fat liquid diet with either ethanol or isocaloric maltose-dextrin for 4 wk. There were no differences in mean urine alcohol concentrations between the groups fed ethanol. Alcohol administration significantly increased liver size and serum alanine aminotransferase levels in wild-type mice over high-fat controls, effects that were blunted significantly in ICAM-1 knockout mice. Dietary ethanol caused severe steatosis, mild inflammation, and focal necrosis in livers from wild-type mice. Furthermore, livers from wild-type mice fed ethanol showed significant increases in the number of infiltrating leukocytes, which were predominantly lymphocytes. These pathological changes were blunted significantly in ICAM-1 knockout mice. Tumor necrosis factor (TNF)-alpha mRNA expression was increased in wild-type mice fed ethanol but not in ICAM-1 knockout mice. These data demonstrate that ICAM-1 and infiltrating leukocytes play important roles in early alcohol-induced liver injury, most likely by mechanisms involving TNF-alpha .

intragastric feeding; adhesion molecules


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
B. Vollmar and M. D. Menger
The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair
Physiol Rev, October 1, 2009; 89(4): 1269 - 1339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
I. N. Hines and M. D. Wheeler
Recent Advances in Alcoholic Liver Disease III. Role of the innate immune response in alcoholic hepatitis
Am J Physiol Gastrointest Liver Physiol, August 1, 2004; 287(2): G310 - G314.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Horie, Y. Yamagishi, S. Kato, M. Kajihara, H. Tamai, D. N. Granger, and H. Ishii
Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats
Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G537 - G543.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Uesugi, M. Froh, G. E. Arteel, B. U. Bradford, M. D. Wheeler, E. Gabele, F. Isayama, and R. G. Thurman
Role of Lipopolysaccharide-Binding Protein in Early Alcohol-Induced Liver Injury in Mice
J. Immunol., March 15, 2002; 168(6): 2963 - 2969.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online