AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 281: G164-G172, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, M. W.
Right arrow Articles by Travagli, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, M. W.
Right arrow Articles by Travagli, R. A.
Vol. 281, Issue 1, G164-G172, July 2001

Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus

Mark W. Lewis and R. Alberto Travagli

Division of Gastroenterology and Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109

Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and characterizing pharmacologically the SP response. Using whole cell patch-clamp recordings from identified gastrointestinal-projecting vagal motoneurons, we found that SP induced an inward current in all neuronal groups except for cecum-projecting cells. The lowest percentage of SP-responding neurons was found in fundus-projecting cells, where SP also had a concentration-response curve that was shifted to the left (P < 0.05). Independently from the projections, the SP response was reduced by sendide and MEN 10,376 and mimicked by a combination of [Sar9-Met(O2)11]SP and alpha -neurokinin. SP and alpha -neurokinin also increased the frequency, but not the amplitude, of postsynaptic currents. In conclusion, we demonstrated that SP induces both pre- and postsynaptic effects on DMV neurons via activation of neurokinin NK1 and NK2 receptors. The magnitude of the SP response was correlated to the peripheral target organ.

neurokinin; electrophysiology; brain stem; gastrointestinal tract


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
T. Suwabe and R. M. Bradley
Effects of 5-Hydroxytryptamine and Substance P on Neurons of the Inferior Salivatory Nucleus
J Neurophysiol, April 1, 2007; 97(4): 2605 - 2611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. T. Cruz, E. C. Murphy, N. Sahibzada, J. G. Verbalis, and R. A. Gillis
A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R291 - R307.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. Sato, Y. Okada, T. Miyazaki, Y. Kato, and K. Toda
Taste Cell Responses in the Frog Are Modulated by Parasympathetic Efferent Nerve Fibers
Chem Senses, November 1, 2005; 30(9): 761 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. N. Browning, F. H. Coleman, and R. A. Travagli
Characterization of pancreas-projecting rat dorsal motor nucleus of vagus neurons
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G950 - G955.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. A. Travagli, G. E. Hermann, K. N. Browning, and R. C. Rogers
Musings on the Wanderer: What's New in our Understanding of Vago-Vagal Reflexes?: III. Activity-dependent plasticity in vago-vagal reflexes controlling the stomach
Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G180 - G187.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online