AJP - GI Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 281: G44-G53, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dong, H.
Right arrow Articles by Bieger, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dong, H.
Right arrow Articles by Bieger, D.
Vol. 281, Issue 1, G44-G53, July 2001

Vagal afferent input determines the volume dependence of rat esophageal motility patterns

Haiheng Dong1, Christopher W. Loomis2, and Detlef Bieger1

1 Division of Basic Medical Sciences, Faculty of Medicine, and 2 School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6

The volume dependence of balloon distension-evoked esophageal rhythmic motor responses and their neural correlates was investigated in 72 urethane-anesthetized rats. With increasing balloon volume (75-200 µl), distal esophageal rhythmic contractions decreased in rate and became tonic in the range of 150-250 µl. This change in motor pattern involved only the striated musculature of the esophageal body and persisted after acute transection of the spinal cord at C2. Impulse frequency in single vagal afferents of the distal esophagus increased with intraluminal pressure over the entire range of balloon volumes tested (50-300 µl). Distension-responsive neurons in the nucleus tractus solitarii showed rhythmic burst activity (type I), tonic excitation (type II), or inhibition followed by off bursts (type III). Increasing strength of stimulation changed type I responses to nonrhythmic but intensified type II and III responses. We conclude that load-dependent changes in distal esophagus motility pattern are encoded by vagal afferents alone and do not involve a spinal afferent input even at near-noxious stimulus strengths.

esophagus; nucleus tractus solitarii; nucleus ambiguus; visceral pain


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Qin, J. P. Farber, and R. D. Foreman
Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats
Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G708 - G716.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. K. M. Lennerz, C. Dentsch, N. Bernardini, T. Hummel, W. L. Neuhuber, and P. W. Reeh
Electrophysiological characterization of vagal afferents relevant to mucosal nociception in the rat upper oesophagus
J. Physiol., July 1, 2007; 582(1): 229 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Ferreria Jr., N. Sahibzada, J. G. Verbalis, R. A. Gillis, G. E. Hermann, E. Seeliger, M. Ladwig, and H. W. Reinhardt
Comments on: "Esophageal-gastric relaxation reflex in rat: dual control of peripheral nitrergic and cholinergic transmission"
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R854 - R855.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. E. Hermann, R. A. Travagli, and R. C. Rogers
Esophageal-gastric relaxation reflex in rat: dual control of peripheral nitrergic and cholinergic transmission
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1570 - R1576.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. C. Rogers, G. E. Hermann, R. A. Travagli, M. Ferreira Jr., N. Sahibzada, M. Shi, M. Niedringhaus, M. R. Wester, A. R. Jones, J. G. Verbalis, et al.
Comments on "Hindbrain chemical mediators of reflex-induced inhibition of gastric tone produced by esophageal distension and intravenous nicotine"
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1151 - R1152.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online