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Am J Physiol Gastrointest Liver Physiol 281: G560-G568, 2001;
0193-1857/01 $5.00
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Vol. 281, Issue 2, G560-G568, August 2001

Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats

Pu-Qing Yuan, Yvette Taché, Marcel Miampamba, and Hong Yang

CURE: Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California, Los Angeles, California 90073

Acute cold exposure-induced activation of gastric myenteric neurons in conscious rats was examined on longitudinal muscle-myenteric plexus whole mount preparations. Few Fos-immunoreactive (IR) cells (<1/ganglion) were observed in 24-h fasted rats semirestrained at room temperature. Cold exposure (4°C) for 1-3 h induced a time-related increase of Fos-IR cells in corpus and antral myenteric ganglia with a maximal plateau response (17 ± 3 and 18 ± 3 cells/ganglion, respectively) occurring at 2 h. Gastric vagotomy partly prevented, whereas bilateral cervical vagotomy completely abolished, Fos expression in the myenteric cells induced by cold exposure (2 h). Hexamethonium (20 mg/kg) also prevented 3-h cold exposure-induced myenteric Fos expression by 76-80%, whereas atropine or bretylium had no effect. Double labeling revealed that cold (3 h)-induced Fos-IR myenteric cells were mainly neurons, including a substantial number of choline acetyltransferase-containing neurons and most NADPH-diaphorase-positive neurons. These results indicate that acute cold exposure activates cholinergic as well as nitrergic neurons in the gastric myenteric ganglia through vagal nicotinic pathways in conscious rats.

bretylium; nicotamide adenine dinucleotide phosphate-diaphorase; hexamethonium; atropine


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