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Am J Physiol Gastrointest Liver Physiol 281: G666-G674, 2001;
0193-1857/01 $5.00
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Vol. 281, Issue 3, G666-G674, September 2001

GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation

Lan Jiang1, Elmer S. David2, Noel Espina3, and Ronaldo P. Ferraris4

1 Graduate School of the Biomedical Sciences and Departments of 2 Pediatrics, 3 Anatomy, Cell Biology, and Injury Sciences, and 4 Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, New Jersey 07103-2714

The rat fructose transporter normally appears after completion of weaning but can be precociously induced by early feeding of a high-fructose diet. In this study, the crypt-villus site, the metabolic nature of the signal, and the age dependence of induction were determined. In weaning rats fed high-glucose pellets, GLUT-5 mRNA expression was modest, localized mainly in the upper three-fourths of the villus, and there was little expression in the villus base. When fed high-fructose pellets, GLUT-5 mRNA expression was two to three times greater in all regions except the villus base. Intestinal perfusion in vivo of a nonmetabolizable fructose analog, 3-O-methylfructose, tended to increase fructose uptake rate and moderately increased GLUT-5 mRNA abundance but had no effect on glucose uptake rates and SGLT1 mRNA abundance. Gavage feeding of high-fructose, but not high-glucose, solutions enhanced fructose uptake only in pups >= 14 days, suggesting that GLUT-5 regulation is markedly age dependent. Fructose or its metabolites upregulate GLUT-5 expression in all enterocytes, except those in the crypt and villus base and in pups <14 days old.

membranes; metabolism; sugars; transport; small intestine


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