AJP - GI Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 281: G764-G778, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (60)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burich, A.
Right arrow Articles by Maggio-Price, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burich, A.
Right arrow Articles by Maggio-Price, L.
Vol. 281, Issue 3, G764-G778, September 2001

Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice

Andrew Burich1,5, Robert Hershberg3, Kim Waggie4, Weiping Zeng1, Thea Brabb1,2, Gina Westrich5, Joanne L. Viney5, and Lillian Maggio-Price1,5

Departments of 1 Comparative Medicine and 2 Molecular Biotechnology, University of Washington, Seattle 98195; 3 Corixa Corporation, Seattle 98104; 4 Zymogenetics Incorporated, Seattle 98102; and 5 Department of Molecular Immunology, Immunex Corporation, Seattle, Washington 98101

Inflammatory bowel disease (IBD) is thought to result from a dysregulated mucosal immune response to luminal microbial antigens, with T lymphocytes mediating the colonic pathology. Infection with Helicobacter spp has been reported to cause IBD in immunodeficient mice, some of which lack T lymphocytes. To further understand the role of T cells and microbial antigens in triggering IBD, we infected interleukin (IL)-10-/-, recombinase-activating gene (Rag)1-/-, T-cell receptor (TCR)-alpha -/-, TCR-beta -/-, and wild-type mice with Helicobacter hepaticus or Helicobacter bilis and compared the histopathological IBD phenotype. IL-10-/- mice developed severe diffuse IBD with either H. bilis or H. hepaticus, whereas Rag1-/-, TCR-alpha -/-, TCR-beta -/-, and wild-type mice showed different susceptibilities to Helicobacter spp infection. Proinflammatory cytokine mRNA expression was increased in the colons of Helicobacter-infected IL-10-/- and TCR-alpha -/- mice with IBD. These results confirm and extend the role of Helicobacter as a useful tool for investigating microbial-induced IBD and show the importance, but not strict dependence, of T cells in the development of bacterial-induced IBD.

Helicobacter bilis; Helicobacter hepaticus; colitis; proinflammatory cytokines


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Chichlowski and L. P. Hale
Bacterial-mucosal interactions in inflammatory bowel disease--an alliance gone bad
Am J Physiol Gastrointest Liver Physiol, December 1, 2008; 295(6): G1139 - G1149.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
P. Pisani, M. T. Whary, I. Nilsson, S. Sriamporn, T. Wadstrom, J. G. Fox, A. Ljungh, and D. Forman
Cross-Reactivity between Immune Responses to Helicobacter bilis and Helicobacter pylori in a Population in Thailand at High Risk of Developing Cholangiocarcinoma
Clin. Vaccine Immunol., September 1, 2008; 15(9): 1363 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Nagamine, J. J. Sohn, B. H. Rickman, A. B. Rogers, J. G. Fox, and D. B. Schauer
Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2-/- ApcMin/+ Mouse
Infect. Immun., June 1, 2008; 76(6): 2758 - 2766.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A. E Jergens, J. H Wilson-Welder, A. Dorn, A. Henderson, Z. Liu, R. B Evans, J. Hostetter, and M. J Wannemuehler
Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice
Gut, July 1, 2007; 56(7): 934 - 940.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Sterzenbach, S. K. Lee, B. Brenneke, F. von Goetz, D. B. Schauer, J. G. Fox, S. Suerbaum, and C. Josenhans
Inhibitory Effect of Enterohepatic Helicobacter hepaticus on Innate Immune Responses of Mouse Intestinal Epithelial Cells
Infect. Immun., June 1, 2007; 75(6): 2717 - 2728.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. M. Schmitz, V. J. McCracken, R. A. Dimmitt, and R. G. Lorenz
Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs
J. Histochem. Cytochem., May 1, 2007; 55(5): 515 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. T. Whary, S. J. Danon, Y. Feng, Z. Ge, N. Sundina, V. Ng, N. S. Taylor, A. B. Rogers, and J. G. Fox
Rapid Onset of Ulcerative Typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) Mice Infected with Helicobacter trogontum Is Associated with Decreased Colonization by Altered Schaedler's Flora
Infect. Immun., December 1, 2006; 74(12): 6615 - 6623.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Maggio-Price, P. Treuting, W. Zeng, M. Tsang, H. Bielefeldt-Ohmann, and B. M. Iritani
Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice
Cancer Res., January 15, 2006; 66(2): 828 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Veterinary PathologyHome page
P. R. Nambiar, S. M. Kirchain, K. Courmier, S. Xu, N. S. Taylor, E. J. Theve, M. M. Patterson, and J. G. Fox
Progressive Proliferative and Dysplastic Typhlocolitis in Aging Syrian Hamsters Naturally Infected with Helicobacter spp.: A Spontaneous Model of Inflammatory Bowel Disease
Veterinary Pathology, January 1, 2006; 43(1): 2 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
H.-O. Nilsson, I.-S. Ouis, U. Stenram, A. Ljungh, A. P. Moran, T. Wadstrom, and W. A. Al-Soud
High Prevalence of Helicobacter Species Detected in Laboratory Mouse Strains by Multiplex PCR-Denaturing Gradient Gel Electrophoresis and Pyrosequencing
J. Clin. Microbiol., August 1, 2004; 42(8): 3781 - 3788.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. B. Young, K. A. Knox, J. S. Pratt, J. S. Cortez, L. S. Mansfield, A. B. Rogers, J. G. Fox, and D. B. Schauer
In Vitro and In Vivo Characterization of Helicobacter hepaticus Cytolethal Distending Toxin Mutants
Infect. Immun., May 1, 2004; 72(5): 2521 - 2527.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. J. Streutker, C. N. Bernstein, V. L. Chan, R. H. Riddell, and K. Croitoru
Detection of Species-Specific Helicobacter Ribosomal DNA in Intestinal Biopsy Samples from a Population-Based Cohort of Patients with Ulcerative Colitis
J. Clin. Microbiol., February 1, 2004; 42(2): 660 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F.-F. Chu, R. S. Esworthy, P. G. Chu, J. A. Longmate, M. M. Huycke, S. Wilczynski, and J. H. Doroshow
Bacteria-Induced Intestinal Cancer in Mice with Disrupted Gpx1 and Gpx2 Genes
Cancer Res., February 1, 2004; 64(3): 962 - 968.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
G-T Ho, F M Moodie, and J Satsangi
Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?
Gut, May 1, 2003; 52(5): 759 - 766.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
S. E. Erdman, T. Poutahidis, M. Tomczak, A. B. Rogers, K. Cormier, B. Plank, B. H. Horwitz, and J. G. Fox
CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice
Am. J. Pathol., February 1, 2003; 162(2): 691 - 702.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. J. Maloy, L. Salaun, R. Cahill, G. Dougan, N. J. Saunders, and F. Powrie
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
J. Exp. Med., January 6, 2003; 197(1): 111 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. J. Engle, I. Ormsby, S. Pawlowski, G. P. Boivin, J. Croft, E. Balish, and T. Doetschman
Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice
Cancer Res., November 15, 2002; 62(22): 6362 - 6366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Maggio-Price, D. Shows, K. Waggie, A. Burich, W. Zeng, S. Escobar, P. Morrissey, and J. L. Viney
Helicobacter bilis Infection Accelerates and H. hepaticus Infection Delays the Development of Colitis in Multiple Drug Resistance-Deficient (mdr1a-/-) Mice
Am. J. Pathol., February 1, 2002; 160(2): 739 - 751.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online