AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 281: G1129-G1134, 2001;
0193-1857/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huizinga, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huizinga, J. D.
Vol. 281, Issue 5, G1129-G1134, November 2001

THEME
Physiology and Pathophysiology of the Interstitial Cell of Cajal: From Bench to Bedside
II. Gastric motility: lessons from mutant mice on slow waves and innervation

Jan D. Huizinga

McMaster University, Hamilton L8N 3Z5, Ontario, Canada

The stomach harbors a network of interstitial cells of Cajal (ICC) associated with Auerbach's plexus as well as intramuscular ICC within the muscle layers that make close apposition contact with nerve varicosities. ICC are critical for slow-wave generation, making ICC the pacemaker cells of the gut, allowing rhythmic peristaltic motor patterns in the mid- and distal stomach. ICC also play a role in neurotransmission, but its importance relative to direct muscle innervation is still under investigation. The role of ICC in many control functions of gastric motility in humans needs further examination. The pathophysiology of ICC in disease can be partially assessed by immunohistochemistry and electron microscopy on tissue samples. Electrogastrogram measurements may also play a role, but this technique needs further refinement. Communication between ICC and muscle may involve electrical coupling, metabolic coupling through gap junctions, or secretion of nitric oxide or carbon monoxide.

interstitial cells of Cajal; stomach; gastric emptying; innervation; distension


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. D. Huizinga, L. W. C. Liu, A. Fitzpatrick, E. White, S. Gill, X.-Y. Wang, N. Zarate, L. Krebs, C. Choi, T. Starret, et al.
Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G589 - G594.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
F de Lorijn, W J de Jonge, T Wedel, J M Vanderwinden, M A Benninga, and G E Boeckxstaens
Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex
Gut, August 1, 2005; 54(8): 1107 - 1113.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online