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Am J Physiol Gastrointest Liver Physiol 281: G1221-G1227, 2001;
0193-1857/01 $5.00
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Vol. 281, Issue 5, G1221-G1227, November 2001

Dietary induction of angiotensin-converting enzyme in proximal and distal rat small intestine

Roger H. Erickson, Byung-Chul Yoon, Danielle Y. Koh, Do Hyong Kim, and Young S. Kim

Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco 94121; and Department of Medicine, University of California, San Francisco, California 94143

Induction of angiotensin-converting enzyme was examined in proximal and distal intestinal segments of rats fed a low-protein (4%) diet and then switched to a high-protein (gelatin) diet. Animals were killed at varying time points, and brush-border membranes and total RNA were prepared from the segments. In the proximal intestine, there was a fivefold increase in angiotensin-converting enzyme levels after 14 days but only a twofold change in mRNA. In the distal intestine, there was no increase in enzyme activity but mRNA increased 2.4-fold. Organ culture was used to measure changes in enzyme biosynthesis. There was a 5- to 6-fold increase in the biosynthesis of angiotensin-converting enzyme in the proximal intestine 24 h after the switch to the gelatin diet and a 1.6-fold increase in mRNA levels. No change in biosynthesis was observed in the distal small intestine despite an increase in mRNA. These results support the conclusion that rapid dietary induction of intestinal angiotensin-converting enzyme is differentially regulated in proximal and distal segments of the small intestine.

brush-border membrane; peptidase; biosynthesis


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