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Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242
Splanchnic nerve fibers innervating
the stomach were studied in anesthetized rats; 997 fibers in the
T9 or T10 dorsal roots were identified by
electrical stimulation of the splanchnic nerve. Thirty-one fibers
responded to gastric distension. Extrapolated response thresholds
ranged between 0 and 53 mmHg; seven fibers had thresholds for response
30 mmHg. Thermo- and/or chemosensitivity was tested in 18 of the 31 fibers. Four of twelve fibers responded to intragastric perfusion of
heated saline; none of eight fibers tested responded to perfusion of
cold saline. Infusion of glucose, L-arginine, or potassium
oleate produced no change in resting activity. Intragastric
instillation of 12% glycerol or an inflammatory soup (bradykinin
10
5 M, PGE2 105 M, serotonin
105 M, histamine 105 M, and KCl
103 M) and prior heat stimulation sensitized responses to
distension. The results reveal the presence of low- and high-threshold
mechanosensitive fibers in the splanchnic innervation of the stomach.
These fibers have the ability to sensitize, and they likely contribute
to pain and altered sensations that can arise from the stomach.
visceral pain; sensitization; thermosensitivity; chemosensitivity; functional gastrointestinal disorders
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