AJP - GI Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 282: G175-G183, 2002. First published October 17, 2001; doi:10.1152/ajpgi.00287.2001
0193-1857/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/1/G175    most recent
00287.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zavros, Y.
Right arrow Articles by Merchant, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zavros, Y.
Right arrow Articles by Merchant, J. L.
Vol. 282, Issue 1, G175-G183, January 2002

Hypergastrinemia in response to gastric inflammation suppresses somatostatin

Yana Zavros1, Gabriele Rieder2, Amy Ferguson3, Linda C. Samuelson4, and Juanita L. Merchant1,2,4

1 Howard Hughes Medical Institute and the Departments of 2 Internal Medicine, 4 Physiology, and 3 Pathology University of Michigan, Ann Arbor, Michigan 48109 - 0650

Hypergastrinemia and a reduction in tissue somatostatin occur in Helicobacter pylori-infected patients. We investigated whether the D cell may be a direct target of gastric inflammation and hypergastrinemia. D cells were quantified by morphometry and flow cytometry in 16-wk-old wild-type (G+/+) and gastrin-deficient (G-/-) mice. Hypochlorhydric G-/- mice were treated with either antibiotics for 20 days or infused with gastrin (G-17) for 14 days. G+/+ mice were made hypochlorhydric by treating them with omeprazole for 2 mo. G-/- mice showed significant inflammation compared with the G+/+ mice, which resolved after 20 days of antibiotic treatment. D cell numbers were not significantly different between G-/- and G+/+ mice. After G-17 was infused, fundic and antral D cell numbers decreased in the G-/- mice. G+/+ animals made hypergastrinemic with omeprazole exhibited decreased D cell numbers. When omeprazole-treated mice were treated with antibiotics alone, elevated plasma gastrin levels returned to baseline and D cell numbers returned to resting levels despite persistent hypochlorhydria. Hypergastrinemia, induced by inflammation, results in decreased D cell numbers. Thus the stomach responds to the presence of inflammation by reducing somatostatin levels, thereby releasing the inhibition on the G and parietal cells to maximize gastric acid output.

Helicobacter pylori; bacterial overgrowth; omeprazole; gastrin-null mice; mucosal lymphocytes.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. Mensah-Osman, Y. Zavros, and J. L. Merchant
Somatostatin stimulates menin gene expression by inhibiting protein kinase A
Am J Physiol Gastrointest Liver Physiol, October 1, 2008; 295(4): G843 - G854.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Y. Choi, A. I. Romer, Y. Wang, M. P. Wu, S. Ito, A. B. Leiter, and R. A. Shivdasani
Requirement of the Tissue-Restricted Homeodomain Transcription Factor Nkx6.3 in Differentiation of Gastrin-Producing G Cells in the Stomach Antrum
Mol. Cell. Biol., May 15, 2008; 28(10): 3208 - 3218.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
K Fujino, S G de la Fuente, Y Takami, T Takahashi, and C R Mantyh
Attenuation of acid induced oesophagitis in VR-1 deficient mice
Gut, January 1, 2006; 55(1): 34 - 40.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Cui, T. J. Koh, D. Chen, C.-M. Zhao, S. Takaishi, G. J. Dockray, A. Varro, A. B. Rogers, J. G. Fox, and T. C. Wang
Overexpression of Glycine-Extended Gastrin Inhibits Parietal Cell Loss and Atrophy in the Mouse Stomach
Cancer Res., November 15, 2004; 64(22): 8160 - 8166.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Zavros, S. Rathinavelu, J. Y. Kao, A. Todisco, J. Del Valle, J. V. Weinstock, M. J. Low, and J. L. Merchant
Treatment of Helicobacter gastritis with IL-4 requires somatostatin
PNAS, October 28, 2003; 100(22): 12944 - 12949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. L. Hinkle, G. C. Bane, A. Jazayeri, and L. C. Samuelson
Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice
Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G145 - G153.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. M. Kirton, T. Wang, and G. J. Dockray
Regulation of parietal cell migration by gastrin in the mouse
Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G787 - G793.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online