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Am J Physiol Gastrointest Liver Physiol 282: G69-G76, 2002;
0193-1857/02 $5.00
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Vol. 282, Issue 1, G69-G76, January 2002

Increased lymphatic lipid transport in genetically diabetic obese rats

Hiroshi Hayashi1,2, Yuko Sato2, Setsuko Kanai2, Mineko Ichikawa3, Akihiro Funakoshi4, and Kyoko Miyasaka2

1 Department of Internal Medicine, Yokohama Red Cross Hospital, Yokohama 231-0836; Departments of 2 Clinical Physiology and 3 Nutrition, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015; and 4 Division of Gastroenterology, National Kyushu Cancer Center, Fukuoka 813-1394, Japan

Otsuka Long-Evans Tokushima fatty (OLETF) rats are a model for noninsulin-dependent diabetes mellitus (NIDDM), which is first manifested at 18 wk of age. We assessed age-related changes in lymphatic lipid transport in the intestine of OLETF rats and compared them with those of control Long-Evans Tokushima Otsuka (LETO) rats. Olive oil was infused into the rats with a mesenteric lymph fistula, which was created under ethrane anesthesia. A significant increase in lymphatic triglyceride (TG) transport in OLETF rats was observed at 18-19 wk compared with under 17 wk, but no age-related change was observed in LETO rats. Food restriction, exercise training, or troglitazone treatment in OLETF rats prevented the age-related increase in lipid transport. Biliary phosphatidylcholine concentration was higher in OLETF rats than in LETO rats, but no difference was seen in bile acid concentrations or the activity of microsomal TG transfer protein between the two strains. This study shows that increased lipid transport in the intestine may occur in NIDDM.

lymph fistula rats; noninsulin-dependent diabetes mellitus; triglyceride; biliary phosphatidylcholine; troglitazone


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