| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Veterinary Preclinical Sciences, The University of Liverpool, Liverpool L69 7ZJ; and 2 Department of Medicine, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom
Noninsulin-dependent diabetes
mellitus (NIDDM) is an increasingly common disease, which brings
a number of life-threatening complications. In rats with experimentally
induced diabetes, there is an increase in the capacity of the intestine
to absorb monosaccharides. We have examined the activity and the
expression of monosaccharide transporters in the intestine of patients
suffering from NIDDM. Na+-dependent D-glucose
transport was 3.3-fold higher in brush-border membrane (BBM) vesicles
isolated from duodenal biopsies of NIDDM patients compared with healthy
controls. Western analysis indicated that SGLT1 and GLUT5 protein
levels were also 4.3- and 4.1-fold higher in diabetic patients. This
was associated with threefold increases in SGLT1 and GLUT5 mRNA
measured by Northern blotting. GLUT2 mRNA levels were also increased
threefold in the intestine of diabetic patients. Analysis of other BBM
proteins indicated that the activity and abundance of sucrase and
lactase were increased by 1.5- to 2-fold and the level of the
structural proteins villin and 
-actin was enhanced 2-fold in
diabetic patients compared with controls. The increase in the capacity
of the intestine to absorb monosaccharides in human NIDDM is due to a
combination of intestinal structural change with a specific increase in
the expression of the monosaccharide transporters SGLT1, GLUT5, and GLUT2.
noninsulin-dependent diabetes mellitus; SGLT1; GLUT5; GLUT2; human intestine
This article has been cited by other articles:
|
|
 |
|
  R L Young, K Sutherland, N Pezos, S M Brierley, M Horowitz, C K Rayner, and L A Blackshaw Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes Gut, March 1, 2009; 58(3): 337 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ravid, M. Bendayan, E. Delvin, A. T. Sane, M. Elchebly, J. Lafond, M. Lambert, G. Mailhot, and E. Levy Modulation of intestinal cholesterol absorption by high glucose levels: impact on cholesterol transporters, regulatory enzymes, and transcription factors Am J Physiol Gastrointest Liver Physiol, November 1, 2008; 295(5): G873 - G885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miro-Queralt, J. J. Guinovart, and J. M. Planas Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G479 - G484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Douard and R. P. Ferraris Regulation of the fructose transporter GLUT5 in health and disease Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E227 - E237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R J. Hine Time to get specific about dietary carbohydrates, affected populations, and diseases Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1062 - 1062. [Full Text] [PDF]
|
|
|
|
|
|
A. T. Stearns, A. Balakrishnan, J. Rounds, D. B. Rhoads, S. W. Ashley, and A. Tavakkolizadeh Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1 Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G1078 - G1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Stuart, M. E.A. Howell, and D. Yin Overexpression of GLUT5 in Diabetic Muscle Is Reversed by Pioglitazone Diabetes Care, April 1, 2007; 30(4): 925 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Stuart, D. Yin, M. E. A. Howell, R. J. Dykes, J. J. Laffan, and A. A. Ferrando Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1067 - E1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Rahmoune, P. W. Thompson, J. M. Ward, C. D. Smith, G. Hong, and J. Brown Glucose Transporters in Human Renal Proximal Tubular Cells Isolated From the Urine of Patients With Non-Insulin-Dependent Diabetes Diabetes, December 1, 2005; 54(12): 3427 - 3434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Kellett and E. Brot-Laroche Apical GLUT2: A Major Pathway of Intestinal Sugar Absorption Diabetes, October 1, 2005; 54(10): 3056 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Cui, A. M. Schlesier, E. L. Fisher, C. Cerqueira, and R. P. Ferraris Fructose-induced increases in neonatal rat intestinal fructose transport involve the PI3-kinase/Akt signaling pathway Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1310 - G1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ducroc, S. Guilmeau, K. Akasbi, H. Devaud, M. Buyse, and A. Bado Luminal Leptin Induces Rapid Inhibition of Active Intestinal Absorption of Glucose Mediated by Sodium-Glucose Cotransporter 1 Diabetes, February 1, 2005; 54(2): 348 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mithieux, I. Bady, A. Gautier, M. Croset, F. Rajas, and C. Zitoun Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E370 - E375. [Abstract] [Full Text]
|
|
|
|
 |
|
 F Gouyon, L Caillaud, V Carriere, C Klein, V Dalet, D Citadelle, G L Kellett, B Thorens, A Leturque, and E Brot-Laroche Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice J. Physiol., November 1, 2003; 552(3): 823 - 832. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
