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1 in the development of pancreatic fibrosis in
Otsuka Long-Evans Tokushima Fatty rats
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, 807 - 8555 Japan
Recently established Otsuka Long-Evans
Tokushima Fatty (OLETF) rats, a model of naturally occurring obesity
diabetes, exhibit progressive accumulation of connective tissue in the
pancreas. The present study was designed to determine the pathogenic
role of transforming growth factor-
1 (TGF-1) in the development
of pancreatic fibrosis in OLETF rats by investigating the serial changes in the expression of TGF-1 and extracellular matrix (ECM) in
the pancreas. Progressive proliferation of connective tissue arose from
the interstitial region surrounding islets at 20 wk of age and extended
to the exocrine pancreas adjacent to the islets. TGF-1 mRNA levels
in the pancreas increased at 20 wk of age and reached a peak value at
30 wk of age. Fibronectin (FN) and procollagen types I and III mRNAs
peaked at 20 wk of age and remained at higher levels than those in the
nondiabetic counterparts Long-Evans Tokushima Otsuka rats until 50 wk
of age. Immunoreactivities for TGF-1 and FN were found in islets of
OLETF rats at 20 wk of age and were seen in acinar and interstitial
cells at 50 wk of age. Moreover, 
-smooth muscle actin was located at
interstitial region surrounding the islets. Proliferation of the
connective tissue in the pancreas of OLETF rats closely correlated with
expression of TGF-1 and ECM. Our results suggest that the
development of pancreatic fibrosis in OLETF rats extends from endocrine
to exocrine pancreas and that TGF-1 is involved in pancreatic
fibrosis of OLETF rats.
extracellular matrix; myofibroblast; Type 2 diabetes; pancreatic stellate cell; transforming growth factor-1
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