AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 282: G1052-G1058, 2002; doi:10.1152/ajpgi.00279.2001
0193-1857/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pandolfino, J. E.
Right arrow Articles by Kahrilas, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pandolfino, J. E.
Right arrow Articles by Kahrilas, P. J.
Vol. 282, Issue 6, G1052-G1058, June 2002

Esophagogastric junction distensibility: a factor contributing to sphincter incompetence

John E. Pandolfino, Guoxiang Shi, Jennifer Curry, Raymond J. Joehl, James G. Brasseur, and Peter J. Kahrilas

Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611-3008

To quantify the effect of hiatus hernia (HH) on esophagogastric junction (EGJ) distensibility, eight normal subjects and nine gastroesophageal reflux disease (GERD) patients with HH were studied with concurrent manometry, fluoroscopy, and stepwise controlled barostatic distention of the EGJ. The minimal barostatic pressure required to open the EGJ during the interswallow period was determined. Thereafter, barium swallows were imaged in 5-mmHg increments of intrabag pressure. EGJ diameter and length were measured at each pressure during deglutitive relaxation. The EGJ opening diameter was greater in hernia patients compared with normal subjects during deglutitive relaxation at all pressures, and EGJ length was 23% shorter. EGJ opening pressure among hernia patients was lower than normal subjects during the interswallow period. In conclusion, the EGJ of GERD patients with HH was more distensible and shorter than normal subjects. These findings partially explain why HH patients are predisposed to reflux by mechanisms other than transient lower esophageal sphincter relaxations, sustain greater volumes of refluxate, and have a reduced ability to discriminate gas from liquid reflux.

hiatus hernia; gastroesophageal reflux disease


This article has been cited by other articles:


Home page
 GutHome page
M. Fox and W. Schwizer
Making sense of oesophageal contents
Gut, April 1, 2008; 57(4): 435 - 438.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. K. Ghosh, P. J. Kahrilas, N. Lodhia, and J. E. Pandolfino
Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics
Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G1023 - G1028.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. P. McMahon, J. B. Frokjaer, P. Kunwald, D. Liao, P. Funch-Jensen, A. M. Drewes, and H. Gregersen
The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction
Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G377 - G384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. K. Ghosh, P. J. Kahrilas, T. Zaki, J. E. Pandolfino, R. J. Joehl, and J. G. Brasseur
The mechanical basis of impaired esophageal emptying postfundoplication
Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G21 - G35.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
D Sifrim
Relevance of volume and proximal extent of reflux in gastro-oesophageal reflux disease
Gut, February 1, 2005; 54(2): 175 - 178.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P J Kahrilas and T J Lee
Gatekeeper reflux repair system; a mechanistic hypothesis
Gut, February 1, 2005; 54(2): 179 - 180.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. Shaker, E. Bardan, C. Gu, B. T. Massey, T. Sanders, M. K. Kern, R. G. Hoffmann, and W. J. Hogan
Effect of lower esophageal sphincter tone and crural diaphragm contraction on distensibility of the gastroesophageal junction in humans
Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G815 - G821.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online