AJP - GI Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 283: G180-G186, 2002. First published March 6, 2002; doi:10.1152/ajpgi.00514.2001
0193-1857/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/1/G180    most recent
00514.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Isordia-Salas, I.
Right arrow Articles by Colman, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Isordia-Salas, I.
Right arrow Articles by Colman, R. W.
Vol. 283, Issue 1, G180-G186, July 2002

Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats

Irma Isordia-Salas1,*, Robin A. Pixley1,*, Fengling Li2, Irma Sainz1, R. Balfour Sartor2, Albert Adam3, and Robert W. Colman1

1 The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140; 2 Center for Gastrointestinal Biology and Disease, Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599; and 3 Department of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada

Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis concomitant with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK) in chronic enterocolitis, we back crossed Brown-Norway rats having a HK deficiency with Lewis rats for five generations. Two new strains were produced, wild-type F5 (F5WT) and HK deficient (F5HKd), each with a ~97% Lewis genome. The HK values of F5WT and F5HKd rat plasma were 0.62 ± 0.20 and 0.08 ± 0.03 U/ml, respectively. In PG-APS-injected rats, chronic inflammation was measured by using gross gut score, histological inflammation, liver granuloma, and white blood cell count. The mean gross gut scores were significantly lower in the F5HKd than in the F5WT rats. Plasma T-kininogen was significantly less in F5HKd. These results indicate the importance of the kallikrein-kinin system in this model of chronic enterocolitis and systemic inflammation.

inflammatory bowel disease; experimental colitis; kallikrein-kinin system; contact system

* I. Isordia-Salas and R. A. Pixley contributed equally to this work.




This article has been cited by other articles:


Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
V. Perez, V. Velarde, C. Acuna-Castillo, C. Gomez, S. Nishimura, V. Sabaj, R. Walter, and F. Sierra
Increased Kinin Levels and Decreased Responsiveness to Kinins During Aging
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 984 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Stadnicki, E. Pastucha, G. Nowaczyk, U. Mazurek, D. Plewka, G. Machnik, T. Wilczok, and R. W. Colman
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G361 - G366.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Isordia-Salas, R. A. Pixley, H. Parekh, S. P. Kunapuli, F. Li, A. Stadnicki, Y. Lin, R. B. Sartor, and R. W. Colman
The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation
Blood, October 15, 2003; 102(8): 2835 - 2842.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online