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Am J Physiol Gastrointest Liver Physiol 283: G496-G502, 2002; doi:10.1152/ajpgi.00207.2002
0193-1857/02 $5.00
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Vol. 283, Issue 3, G496-G502, September 2002

THEME
The Epithelial Cell Cytoskeleton and Intracellular Trafficking
III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

Rafika Athman, Daniel Louvard, and Sylvie Robine

Laboratoire de morphogénèse et signalisation cellulaires, Institut Curie UMR 144, 75248 Paris cedex 05, France

Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.

F-actin; gelsolin family; cell motility; Shigella infection


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