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Am J Physiol Gastrointest Liver Physiol 283: G1290-G1297, 2002. First published May 29, 2002; doi:10.1152/ajpgi.00101.2002
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Vol. 283, Issue 6, G1290-G1297, December 2002

Differential transcriptional expression of Ca2+ BP superfamilies in murine gastrointestinal smooth muscles

Susumu Ohya and Burton Horowitz

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557 - 0046

Calmodulin (Cal) plays important roles for contractile activity in smooth muscles. Recently, two distinct Ca2+-binding protein superfamilies with sequence similarities to Cal have been identified in neuronal cells: neuronal Ca2+-binding proteins (NCBPs) and Cal-like Ca2+-binding proteins (CaBPs). Some NCBPs and CaBPs play significant roles for Ca2+-dependent cellular signaling in the nervous system. In gastrointestinal smooth muscles (GISMs), Cal functions as the regulator of contractile behavior and electrical rhythmicity. However, the molecular identification of NCBPs and CaBPs has not been elucidated in GISMs. Here, we have identified NCBPs and CaBPs expressed in GISMs and determined the expression levels of their transcripts by quantitative RT-PCR. Of 12 NCBPs, the transcripts for neuronal Ca2+ sensor 1, neural visinin-like proteins 1, 2, and 3, and K+ channel-interacting proteins 1 and 3 were detected in proximal colon, gastric fundus, gastric antrum, and jejunum. On the other hand, of seven CaBPs including alternatively spliced variants, only CaBP1L transcripts were detected in GISMs.

EF-hand motif; quantitative PCR; ion channel regulation; rhythmicity; contractile activity


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