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Am J Physiol Gastrointest Liver Physiol 284: G175-G179, 2003; doi:10.1152/ajpgi.00409.2002
0193-1857/03 $5.00
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Vol. 284, Issue 2, G175-G179, February 2003

THEME
Bile Acid Regulation of Hepatic Physiology
I. Hepatocyte transport of bile acids

Allan W. Wolkoff and David E. Cohen

Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461

Bile acids are cholesterol derivatives that serve as detergents in bile and the small intestine. Approximately 95% of bile acids secreted by hepatocytes into bile are absorbed from the distal ileum into the portal venous system. Extraction from the portal circulation by the hepatocyte followed by reexcretion into the bile canaliculus completes the enterohepatic circulation of these compounds. Over the past few years, candidate bile acid transport proteins of the sinusoidal and canalicular plasma membranes of the hepatocyte have been identified. The physiology of hepatocyte bile acid transport and its relationship to these transport proteins is the subject of this Themes article.

organic anion transporting protein; Na+-taurocholate cotransporting polypeptide; bile salt export pump


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