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Am J Physiol Gastrointest Liver Physiol 284: G551-G557, 2003; doi:10.1152/ajpgi.00468.2002
0193-1857/03 $5.00
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Vol. 284, Issue 4, G551-G557, April 2003

THEME
Bile Acid Regulation of Hepatic Physiology
III. Regulation of bile acid synthesis: past progress and future challenges

Michael Fuchs

Department of Medicine I, University of Ulm, D-89081 Ulm, Germany

Bile acids, amphipathic detergent-like molecules synthesized from cholesterol, are highly conserved by means of enterohepatic circulation. They participate in the generation of bile flow and biliary lipid secretion and also promote absorption of fat-soluble vitamins and lipids. Conversion of cholesterol to bile acids represents a quantitatively important route to eliminate cholesterol from the body. Regulation of bile acid synthesis involves a complex and interrelated group of transcription regulators that link bile acid synthesis to cholesterol and fatty acid metabolism. Targeting key steps of bile acid synthetic pathways as well as the metabolic network that maintains homeostatic levels of lipids should provide exciting novel opportunities for the treatment of cardiovascular and liver diseases.

cholesterol; sterol carrier protein 2; steroid acute response; transcription factors; atherosclerosis


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