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Am J Physiol Gastrointest Liver Physiol 284: G748-G755, 2003. First published January 22, 2003; doi:10.1152/ajpgi.00295.2002
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Vol. 284, Issue 5, G748-G755, May 2003

Spatial localization and properties of pacemaker potentials in the canine rectoanal region

V. N. Mutafova-Yambolieva, K. O'Driscoll, A. Farrelly, S. M. Ward, and K. D. Keef

Department of Physiology and Cell Biology, University of Nevada, Reno, Nevada 89557

The present study investigated the spatial organization of electrical activity in the canine rectoanal region and its relationship to motility patterns. Contraction and resting membrane potential (Em) were measured from strips of circular muscle isolated 0.5-8 cm from the anal verge. Rapid frequency [25 cycles/min (cpm)] Em oscillations (MPOs, 12 mV amplitude) were present across the thickness of the internal anal sphincter (IAS; 0.5 cm) and Em was constant (-52 mV). Between the IAS and the proximal rectum an 18 mV gradient in Em developed across the muscle thickness with the submucosal edge at -70 mV and MPOs were replaced with slow waves (20 mV amplitude, 6 cpm). Slow waves were of greatest amplitude at the submucosal edge. Nifedipine (1 µM) abolished MPOs but not slow waves. Contractile frequency changes were commensurate with the changes in pacemaker frequency. Our results suggest that changing motility patterns in the rectoanal region are associated with differences in the characteristics of pacemaker potentials as well as differences in the sites from which these potentials emanate.

interstitial cells of Cajal; smooth muscle; membrane potential; internal anal sphincter; rectum


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