Vol. 284, Issue 5, G776-G781, May 2003
Motilin effects on the proximal stomach in patients with
functional dyspepsia and healthy volunteers
Ingrid M. C.
Kamerling1,
Aernout D.
Van Haarst1,
Jacobus
Burggraaf1,
Rik C.
Schoemaker1,
Izak
Biemond2,
Hartmut
Heinzerling3,
Richard
Jones3,
Adam F.
Cohen1, and
Ad A. M.
Masclee2
1 Centre for Human Drug Research, 2333 CL Leiden,
The Netherlands, 2 Department of
Gastroenterology, Leiden University Medical Center, 2333 AZ Leiden,
The Netherlands; and 3 Johnson and
Johnson Pharmaceutical Research and Development, HP14 GT High Wycombe,
United Kingdom
This study investigates motilin
effects on the proximal stomach in patients with functional dyspepsia
(FD) and healthy volunteers. Eight healthy volunteers and 12 patients
with FD were infused with synthetic motilin or placebo. Proximal
gastric volume was measured with a barostat at constant pressure and
during isobaric distensions. Abdominal symptoms were scored by visual
analog scales. Plasma motilin concentrations were measured by
radioimmunoassay. Motilin concentrations and baseline gastric volumes
were similar for patients and healthy volunteers. Motilin, compared
with placebo, reduced gastric volume by 112 ml
[F(29,195); confidence interval (CI)
95%] in patients and by 96 ml [F(
7,200); CI
95%] in healthy volunteers. In patients, motilin decreased compliance
by 76 ml/mmHg [F(9,143); CI 95%] compared
with placebo, which was similar in volunteers [66 ml/mmHg;
F(11,120); CI 95%]. Patients were more nauseous during motilin compared with placebo (P = 0.04), whereas healthy volunteers did not experience nausea. We
conclude that in a fasted condition, FD patients have a similar
proximal gastric motor response to motilin as healthy volunteers, but
experience an exaggerated sensation of nausea.
barostat; gastric volume; gastric volume waves
