AJP - GI AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 284: G963-G969, 2003. First published February 12, 2003; doi:10.1152/ajpgi.00218.2002
0193-1857/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/6/G963    most recent
00218.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mondal, M. S.
Right arrow Articles by Nakazato, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mondal, M. S.
Right arrow Articles by Nakazato, M.
Vol. 284, Issue 6, G963-G969, June 2003

Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system

Muhtashan S. Mondal1, Yukari Date1, Noboru Murakami2, Koji Toshinai1, Takuya Shimbara1, Kenji Kangawa3, and Masamitsu Nakazato1

1 Department of Internal Medicine, Miyazaki Medical College, Miyazaki 889 - 1692; 2 Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University, Miyazaki 889 - 2192; and 3 Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka 565 - 8565, Japan

Neuromedin U (NMU) is a hypothalamic peptide involved in energy homeostasis and stress responses. NMU, when administered intracerebroventricularly, decreases food intake and body weight while increasing body temperature and heat production. In addition, NMU, acting via the corticotropin-releasing hormone (CRH) system, induces gross locomotor activity and stress responses. We studied the effect of intracerebroventricularly administered NMU (0.5-4 nmol) in the regulation of gastric functions in conscious rats. Intracerebroventricular administration of NMU significantly decreased gastric acid output to 30-60% and gastric emptying to 35-70% in a dose-dependent manner. Vagotomy did not abolish the inhibitory effect of NMU on pentagastrin-induced gastric acid secretion. Pretreatment with indomethacin (10 mg/kg), an inhibitor of prostaglandin synthesis, also did not affect NMU-induced acid inhibition. Pretreatment with anti-CRH IgG (1 µg/rat), however, completely blocked NMU-induced acid inhibition (P < 0.01). Administration of yohimbine (4 mg/kg), an alpha 2-adrenergic receptor antagonist, also abolished NMU-induced acid inhibition (P < 0.01). These findings suggest that NMU is critical in the central regulation of gastric acid secretion via CRH.

hypothalamic peptide; gastric emptying; corticotropin-releasing hormone; central administration


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Kotz, J. A. Teske, and C. J. Billington
Neuroregulation of nonexercise activity thermogenesis and obesity resistance
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R699 - R710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Vigo, J. Roa, R. Pineda, J. M. Castellano, V. M. Navarro, E. Aguilar, L. Pinilla, and M. Tena-Sempere
Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1265 - E1273.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
T J Kowalski, B D Spar, L Markowitz, M Maguire, A Golovko, S Yang, C Farley, J A Cook, G Tetzloff, L Hoos, et al.
Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice
J. Endocrinol., April 1, 2005; 185(1): 151 - 164.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.