HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Li, Y. Articles by Owyang, C. Search for Related Content PubMed PubMed Citation Articles by Li, Y. Articles by Owyang, C.

THEMES

Musings on the Wanderer: What's New in Our Understanding of Vago-Vagal Reflexes? V. Remodeling of vagus and enteric neural circuitry after vagal injury

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109

The vago-vagal reflexes mediate a wide range of digestive functions such as motility, secretion, and feeding behavior. Previous articles in this series have discussed the organization and functions of this important neural pathway. The focus of this review will be on some of the events responsible for the adaptive changes of the vagus and the enteric neutral circuitry that occur after vagal injury. The extraordinary plasticity of the neural systems to regain functions when challenged with neural injury will be discussed. In general, neuropeptides and transmitter-related enzymes in the vagal sensory neurons are downregulated after vagal injury to protect against further injury. Conversely, molecules previously absent or present at low levels begin to appear or are upregulated and are available to participate in the survival-regeneration process. Neurotrophins and other related proteins made at the site of the lesion and then retrogradely transported to the soma may play an important role in the regulation of neuropeptide phenotype expression and axonal growth. Vagal injury also triggers adaptive changes within the enteric nervous system to minimize the loss of gastrointestinal functions resulting from the interruption of the vago-vagal pathways. These may include rearrangement of the enteric neural circuitry, changes in the electrophysiological properties of sensory receptors in the intramural neural networks, an increase in receptor numbers, and changes in the affinity states of receptors on enteric neurons.

nodose ganglion; neurochemical transmission; enteric nervous system; gastrointestinal motility; pancreatic efferent signaling

This article has been cited by other articles:

				B. C. De Jonghe and C. C. Horn Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R756 - R765. [Abstract] [Full Text] [PDF]

				E. Viard, Z. Zheng, S. Wan, and R. A. Travagli Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G493 - G500. [Abstract] [Full Text] [PDF]

				P. R. R. Gangula, W. L. Maner, M.-A. Micci, R. E. Garfield, and P. J. Pasricha Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G725 - G733. [Abstract] [Full Text] [PDF]

				M. Yoshimoto, M. Sasaki, N. Naraki, M. Mohri, and K. Miki Regulation of gastric motility at simulated high altitude in conscious rats J Appl Physiol, August 1, 2004; 97(2): 599 - 604. [Abstract] [Full Text] [PDF]