HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Yokoyama, Y. Articles by Chaudry, I. H. Search for Related Content PubMed PubMed Citation Articles by Yokoyama, Y. Articles by Chaudry, I. H.

INFLAMMATION/IMMUNITY/MEDIATORS

Role of thromboxane in producing portal hypertension following trauma-hemorrhage

Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294

Submitted 23 June 2003 ; accepted in final form 4 August 2003

Thromboxane A₂ (TXA₂) and endothelin-1 (ET-1) have been proposed as the important vasoconstrictors that increase portal venous resistance in paracrine or autocrine fashion. We hypothesized that the hepatic damage following trauma-hemorrhage (T-H) is induced by the impaired hepatic circulation due to the increased production of vasoconstrictors such as ET-1 and TXA₂ by the liver. To test this, male Sprague-Dawley rats (n = 6/group) were subjected to trauma (i.e., midline laparotomy) and hemorrhage (35-40 mmHg for 90 min followed by fluid resuscitation) or sham operation. At 2 or 5 h after the end of resuscitation, the liver was isolated and perfused and portal inflow pressure, bile flow, and release of ET-1 and thromboxane B₂ (TXB₂; a stable metabolite of TXA₂) into the perfusate were measured. The level of portal pressure was higher at 5 h following T-H compared with 2 h after T-H and sham. The portal pressure was inversely correlated to the amount of bile production. Furthermore, the bile flow was significantly correlated to the hepatic damage as evidenced by release of lactate dehydrogenase into the perfusate. The level of ET-1 at 5 h following T-H in the perfusate after 30 min of recirculation did not show any difference from sham. However, the levels of TXB₂ in the T-H group were significantly higher than those in sham at that interval. These results indicate that the increased release of TXA₂ but not ET-1 following T-H might be responsible for producing the increased portal resistance, decreased bile production, and hepatic damage.

endothelin; portal venous pressure; bile flow

This article has been cited by other articles:

				J.-T. Hsu, W.-H. Kan, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation J. Leukoc. Biol., October 1, 2007; 82(4): 1019 - 1026. [Abstract] [Full Text] [PDF]

				J. G. Kiang, R. M. Peckham, L. E. Duke, T. Shimizu, I. H. Chaudry, and G. C. Tsokos Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway J Appl Physiol, March 1, 2007; 102(3): 933 - 941. [Abstract] [Full Text] [PDF]

				L. Szalay, T. Shimizu, T. Suzuki, H.-P. Yu, M. A. Choudhry, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R812 - R818. [Abstract] [Full Text] [PDF]

				Y. Yokoyama, Y. Nimura, M. Nagino, K. I. Bland, and I. H. Chaudry Role of Thromboxane in Producing Hepatic Injury During Hepatic Stress Arch Surg, August 1, 2005; 140(8): 801 - 807. [Abstract] [Full Text] [PDF]

				T. Shimizu, L. Szalay, M. A. Choudhry, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G244 - G250. [Abstract] [Full Text] [PDF]

				B. Toth, Y. Yokoyama, M. G. Schwacha, R. L. George, L. W. Rue III, K. I. Bland, and I. H. Chaudry Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock J Appl Physiol, December 1, 2004; 97(6): 2184 - 2189. [Abstract] [Full Text] [PDF]