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LIVER AND BILIARY TRACT

Indicial response functions of growth and remodeling of common bile duct postobstruction

¹Department of Biomedical Engineering, University of California, Irvine, California 92697-2715; and ²Center for Sensory-Motor Interaction, Aalborg University and Center of Excellence for Visceral Biomechanics and Pain, Aalborg Hospital, 9220 Aalborg, Denmark

Submitted 18 July 2003 ; accepted in final form 28 September 2003

Biliary duct obstruction is an important clinical condition that stems from cholelithiasis, the neoplasm in the wall or, most commonly, gallbladder stones. The objective of this study is to understand the structural and mechanical remodeling of the common bile duct (CBD) postobstruction. Porcine CBD was ligated near the duodenum that increased the duct's pressure from 6.4 to 18.3 cmH₂O in the first 12 h and to 30.7 cmH₂O after 32 days. The remodeling process was studied after 3 h, 12 h, 2 days, 8 days, and 32 days (n = 5 in each group) after obstruction. One additional animal in each group was sham operated. At each scheduled time, the time course of change of morphometry (diameter, length, wall thickness, etc.) and mechanical properties (stress, strain, etc.) was documented. It was found that the diameter increased by about threefold and the wall thickness of the CBD doubled in the 32-day group compared with the sham group (P < 0.001). The stress and strain increased initially with increase in pressure but recovered to near the control values by day 32 due to the structural and mechanical adaptations. Hence, the net effect of the structural and mechanical remodeling is to restore the stress and strain to their homeostatic values. Furthermore, the strain recovers more rapidly and more completely than stress. Finally, the remodeling data were expressed mathematically in terms of indicial response functions (IRF), i.e., change of a particular feature of a CBD in response to a unit step change of the pressure. The IRF approach provides a quantitative description of the remodeling process in the CBD.

biomechanics; zero-stress state; laplace transform; pressure overload

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