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NEUROREGULATION AND MOTILITY

Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors

¹Center for Neurovisceral Sciences and Women's Health, Departments of Medicine, ²Physiology, ³Psychiatry and Biobehavioral Sciences, and ⁴Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles 90024; and ⁵Veterans Affairs Greater Los Angeles Healthcare System-West Los Angeles Healthcare Center, Los Angeles, California 90073

Submitted 19 August 2003 ; accepted in final form 6 November 2003

The mechanism(s) underlying stress-induced colonic hypersensitivity (SICH) are incompletely understood. Our aims were to assess the acute and delayed (24 h) effect of water avoidance (WA) stress on visceral nociception in awake male Wistar rats and to evaluate the role of two stress-related modulation systems: the substance P/neurokinin-1 receptor (SP/NK₁R) and the corticotropin-releasing factor (CRF)/CRF₁ receptor (CRF/CRF₁R) systems, as well as the possible involvement of the sympathetic nervous system. Visceral pain responses were measured as the visceromotor response to colorectal distension (CRD) at baseline, immediately after WA and again 24 h later. The NK₁R antagonists RP-67580 and SR-140333 and the CRF₁R antagonist CP-154526 were injected 15 min before WA or 1 h before the CRD on day 2. Chemical sympathectomy was performed by repeated injection of 6-hydroxydopamine. WA stress resulted in a significant increase in the visceromotor response on day 2, but no change immediately after WA. Injection of CP-154526 abolished delayed SICH when applied either before WA stress or before the CRD on day 2. Both NK₁R antagonists only decreased SICH when injected before the CRD on day 2. Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK₁R and CRF₁R activation, but not sympathetic nervous system activation, play a role in the development of SICH.

visceral pain; stress

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