AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 287: G192-G201, 2004. First published February 12, 2004; doi:10.1152/ajpgi.00507.2003
0193-1857/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
287/1/G192    most recent
00507.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hilgard, P.
Right arrow Articles by Stockert, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hilgard, P.
Right arrow Articles by Stockert, R. J.

LIVER AND BILIARY TRACT

Proapoptotic function of protein kinase CK2{alpha}" is mediated by a JNK signaling cascade

Philip Hilgard,1 Mark J. Czaja,2 Guido Gerken,1 and Richard J. Stockert2

1Department for Gastroenterology and Hepatology, University-Hospital Essen, 45133 Essen, Germany; and 2Marion Bessin Liver Research Center and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, 10461

Submitted 3 December 2003 ; accepted in final form 6 February 2004

Protein kinase CK2 (formerly casein kinase II) is a tetrameric enzyme constitutively expressed in all eurakyotic tissues that plays a significant role in the regulation of cell proliferation, malignant transformation, and apoptosis. The catalytic {alpha}-subunit of the enzyme is known to exist in three isoforms CK2{alpha}, CK2{alpha}' and CK2{alpha}". CK2{alpha}" is highly expressed in liver compared with other tissues and is required for the normal trafficking of several hepatocellular membrane proteins. Initial studies of dengue virus infection indicated that the CK2{alpha}"-deficient membrane trafficking mutant cell line (Trf1) was resistant to virus-induced cell death compared with the parental human hepatoma (HuH)-7 hepatoma line. Expression of recombinant CK2{alpha}" in Trf1 was capable of reverting this resistant phenotype. This study was extended to TNF-{alpha} in addition to other stimuli of cell death in an attempt to uncover common death pathways that might be modulated by CK2{alpha}". Evaluation of different pathways involved in death signaling suggest that the regulation of a critical proapoptotic step in HuH-7 cells by CK2{alpha}" is mediated by a JNK signaling cascade.

dengue virus; tumor necrosis factor; activator protein-1; casein kinase


Address for reprint requests and other correspondence: R. Stockert, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Ave., Ullmann Bldg. Rm. 611, Bronx, NY, 10461 (E-mail: stockert{at}aecom.yu.edu).




This article has been cited by other articles:


Home page
 Cancer Res.Home page
M. Yu, J. Yeh, and C. Van Waes
Protein Kinase Casein Kinase 2 Mediates Inhibitor-{kappa}B Kinase and Aberrant Nuclear Factor-{kappa}B Activation by Serum Factor(s) in Head and Neck Squamous Carcinoma Cells.
Cancer Res., July 1, 2006; 66(13): 6722 - 6731.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.