HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/1/G72    most recent 00351.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lal, S. Articles by Thompson, D. G. Search for Related Content PubMed PubMed Citation Articles by Lal, S. Articles by Thompson, D. G.

HORMONES AND SIGNALING

Cholecystokinin pathways modulate sensations induced by gastric distension in humans

¹Division of Gastro-Intestinal Sciences, Hope Hospital, University of Manchester, Salford M6 8HD, United Kingdom; ²Rotta Research Laboratory, Monza 20052, Italy; and ³Department of Physiology, University of Liverpool, Liverpool LG9 3BX, United Kingdom

Submitted 14 August 2003 ; accepted in final form 23 January 2004

Ingested fat releases CCK, causes gastric relaxation, delays gastric emptying, and limits meal size; however, the mechanistic link among these actions has not been established. Fatty acid release of CCK is chain-length sensitive; dodecanoic acid (C12) induces greater CCK release than decanoic acid (C10). The effect of C12 or C10 on tolerance to subsequent intragastric infusion of liquid was determined in healthy subjects, with and without the CCK₁ receptor antagonist dexloxiglumide. Gastric wall relaxation after either fatty acid was assessed by graded volume distension and by barostat; gastric emptying was measured by gastric aspiration and by a [¹³C]octanoic acid breath technique. C12 released more CCK (mean plasma CCK after vehicle, 4.7 ± 0.8 pM; C10, 4.8 ± 0.3 pM; C12, 8 ± 1.2 pM; P < 0.05 C12 vs. C10 or vehicle) and reduced the volume of water (and of 5 and 25% glucose solutions) delivered at maximum tolerance compared with C10 or vehicle (volume of water tolerated after vehicle, 1,535 ± 164 ml; C10, 1,335 ± 160 ml; C12, 842 ± 103 ml; P < 0.05 C12 vs. C10 or vehicle); this effect was abolished by dexloxiglumide. Intragastric volumes were always similar at the limit of tolerance, and, whereas gastric relaxation occurred to similar degrees after the fatty acids, its duration was longer after C12, which also induced a longer delay in half-gastric emptying [t_1/2(min) after vehicle, 53 ± 2; C10, 67 ± 3; C12, 88 ± 7; P < 0.05 C12 vs. C10 or vehicle]. In conclusion, ingestion of a CCK-releasing fatty acid reduces the tolerated volume of liquid delivered into the stomach, primarily via a CCK₁ receptor-mediated delay in gastric emptying.

fatty acid; vagus; gastric emptying

This article has been cited by other articles:

				M. Foltz, J. Maljaars, E. A. H. Schuring, R. J. P. van der Wal, T. Boer, G. S. M. Duchateau, H. P. F. Peters, F. Stellaard, and A. A. Masclee Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and appetite Am J Physiol Gastrointest Liver Physiol, May 1, 2009; 296(5): G982 - G991. [Abstract] [Full Text] [PDF]

				S. J. Pandol Integrated Response to a Meal JPEN J Parenter Enteral Nutr, September 1, 2008; 32(5): 564 - 566. [Abstract] [Full Text] [PDF]

				S. Selleri, M. Palazzo, S. Deola, E. Wang, A. Balsari, F. M. Marincola, and C. Rumio Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS Int. Immunol., August 1, 2008; 20(8): 961 - 970. [Abstract] [Full Text] [PDF]

				R. Faipoux, D. Tome, S. Gougis, N. Darcel, and G. Fromentin Proteins Activate Satiety-Related Neuronal Pathways in the Brainstem and Hypothalamus of Rats J. Nutr., June 1, 2008; 138(6): 1172 - 1178. [Abstract] [Full Text] [PDF]

				M P Caldarella, F Azpiroz, and J-R Malagelada Selective effects of nutrients on gut sensitivity and reflexes Gut, January 1, 2007; 56(1): 37 - 42. [Abstract] [Full Text] [PDF]

				J R McDermott, F C Leslie, M D'Amato, D G Thompson, R K Grencis, and J T McLaughlin Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation Gut, April 1, 2006; 55(4): 492 - 497. [Abstract] [Full Text] [PDF]

				T. J. Little, K. L. Feltrin, M. Horowitz, A. J. P. M. Smout, T. Rades, J. H. Meyer, A. N. Pilichiewicz, J. Wishart, and C. Feinle-Bisset Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1090 - R1098. [Abstract] [Full Text] [PDF]

				E. H. E. M. van de Wall, P. Duffy, and R. C. Ritter CCK enhances response to gastric distension by acting on capsaicin-insensitive vagal afferents Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R695 - R703. [Abstract] [Full Text] [PDF]