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Am J Physiol Gastrointest Liver Physiol 288: G151-G158, 2005. First published August 5, 2004; doi:10.1152/ajpgi.00048.2004
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00048.2004v1
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NEUROREGULATION AND MOTILITY

Accelerated intestinal transit in inbred mice with an increased number of interstitial cells of Cajal

Sylvain Bellier,1 Nelly R. Da Silva,1 Geneviève Aubin-Houzelstein,1 Colette Elbaz,1 Jean-Marie Vanderwinden,2 and Jean-Jacques Panthier1

1Unité Mixte de Recherche 955 Institut National de Recherche Agronomique-Ecole Nationale Vétérinaire d’Alfort de Génétique Moléculaire et Cellulaire, Ecole Nationale Vétérinaire d'Alfort, France; and 2Laboratoire de Neurophysiologie, Faculté de Médecine, Université Libre de Bruxelles, Belgium

Submitted 28 January 2004 ; accepted in final form 28 July 2004

The interstitial cells of Cajal (ICC) play an important role in coordinating intestinal motility, and structural alterations in ICC are found in several human digestive diseases. Mouse models with defects in ICC allow a better understanding of their functions. We investigated the pattern of intestinal motility and the distribution of ICC in the PRM/Alf inbred mouse strain, characterized by a selective intestinal lengthening. In PRM/Alf mice, the digestive transit time, evaluated by using thermophilic Bacillus subtilis spores, was normal, indicating accelerated transit. The contractility and slow-wave frequency, recorded on isolated segments from the proximal small intestine, were significantly increased. The number of ICC was also significantly higher along the small intestine and the colon. The concomitant increase of the contractility, the slow-wave frequency, and the number of ICC is consistent with the proposal of a role of ICC number increase in the higher intestinal transit speed. The PRM/Alf model should be useful to further investigate the roles of ICC in the control of digestive motility.

gut length; kit receptor; electrical slow waves; gastrointestinal motility; genetic model


Address for reprint requests and other correspondence: S. Bellier, UMR 955 INRA-ENVA de Génétique Moléculaire et Cellulaire, Ecole Nationale Vétérinaire d'Alfort, 7 Ave. du Général De Gaulle, 94704 Maisons-Alfort Cedex, France (E-mail: sbellier{at}vet-alfort.fr)






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