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THEMES

Signal-Transduction Pathways that Regulate Smooth Muscle Function II. Receptor-ion channel coupling mechanisms in gastrointestinal smooth muscle

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Regulation of membrane ion channels by second messengers is an important mechanism by which gastrointestinal smooth muscle excitability is controlled. Receptor-mediated phosphorylation of Ca²⁺ channels has been known for some time; however, recent findings indicate that these channels may also modulate intracellular signaling. The plasmalemma ion channels may also function as a point of convergence between different receptor types. In this review, the molecular mechanisms that link channel function and signal transduction are discussed. Emerging evidence also indicates altered second-messenger modulation of the Ca²⁺ channel in the pathophysiology of smooth muscle dysmotility.

Ca²⁺ channel; c-src kinase; inactivation facilitation; inflammation

This article has been cited by other articles:

				M. Kang, G. R. Ross, and H. I. Akbarali COOH-terminal association of human smooth muscle calcium channel Cav1.2b with Src kinase protein binding domains: effect of nitrotyrosylation Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1983 - C1990. [Abstract] [Full Text] [PDF]

				G. R. Ross, M. Kang, N. Shirwany, A. P. Malykhina, M. Drozd, and H. I. Akbarali Nitrotyrosylation of Ca2+ Channels Prevents c-Src Kinase Regulation of Colonic Smooth Muscle Contractility in Experimental Colitis J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 948 - 956. [Abstract] [Full Text] [PDF]