AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 289: G377-G380, 2005; doi:10.1152/ajpgi.00093.2005
0193-1857/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flemström, G.
Right arrow Articles by Sjöblom, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flemström, G.
Right arrow Articles by Sjöblom, M.

THEMES

Epithelial Cells and Their Neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells

Gunnar Flemström and Markus Sjöblom

Division of Physiology, Department of Neuroscience, Uppsala University, Uppsala, Sweden

Submitted 1 March 2005 ; accepted in final form 26 April 2005

Surface sensory enteroendocrine cells are established mucosal taste cells that monitor luminal contents and provide an important link in transfer of information from gut epithelium to the central nervous system. Recent studies now show that these cells can also mediate efferent signaling from the brain to the gut. Centrally elicited stimulation of vagal and sympathetic pathways induces release of melatonin, which acts at MT2 receptors to increase mucosal electrolyte secretion. Psychological factors as well mucosal endocrine cell hyperplasia are implicated in functional intestinal disorders. Central nervous influence on the release of transmitters from gut endocrine cells offers an exciting area of future gastrointestinal research with a clinical relevance.

intestinal enterochromaffin cells; irritable bowel syndrome; melatonin; orexin; uroguanylin


Address for reprint requests and other correspondence: G. Flemström, Division of Physiology, Dept. of Neuroscience, Uppsala Univ., BMC, P.O. Box 572, SE-751 23 Uppsala, Sweden (e-mail:Gunnar.Flemstrom{at}Fysiologi.uu.se)




This article has been cited by other articles:


Home page
 Poult. Sci.Home page
M. R. Bakst and V. Akuffo
Serotonin Localization in the Turkey Vaginal but not Sperm Storage Tubule Epithelia
Poult. Sci., February 1, 2008; 87(2): 356 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. W. Bengtsson, K. Makela, M. Sjoblom, S. Uotila, K. E. O. Akerman, K.-H. Herzig, and G. Flemstrom
Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A
Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G501 - G509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Sjoblom and O. Nylander
Isoflurane-induced acidosis depresses basal and PGE2-stimulated duodenal bicarbonate secretion in mice
Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G899 - G904.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.