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Am J Physiol Gastrointest Liver Physiol 289: G631-G635, 2005; doi:10.1152/ajpgi.00220.2005
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THEMES

Iron Imports. I. Intestinal iron absorption and its regulation

David M. Frazer and Gregory J. Anderson

Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia

Submitted 13 May 2005 ; accepted in final form 3 June 2005

Our knowledge of how the body absorbs iron from the diet and how this process is controlled has increased at a rapid rate in recent years. The identification of key molecules, including the iron regulatory peptide hepcidin, and the analysis of how they are regulated and interact have led to the development of an integrated model for the control of iron absorption by body iron requirements. Research now focuses on the role of the liver as the primary regulator of iron absorption, and this review considers some of the recent highlights and controversies in this area.

hepcidin; hemojuvelin; HFE; transferrin receptor 2


Address for reprint requests and other correspondence: G. J. Anderson, Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia (e-mail: Greg.Anderson{at}qimr.edu.au)




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