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Am J Physiol Gastrointest Liver Physiol 290: G189-G193, 2006; doi:10.1152/ajpgi.00041.2005
0193-1857/06 $8.00
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THEMES

Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity

Neil D. Theise

Beth Israel Medical Center, Departments of Pathology and Medicine, Division of Digestive Diseases, New York, New York

This essay will address areas of liver stem/progenitor cell studies in which consensus has emerged and in which controversy still prevails over consensus, but it will also highlight important themes that inevitably should be a focus of liver stem/progenitor cell investigations in coming years. Thus concepts regarding cell plasticity, the existence of a physiological/anatomic stem cell niche, and whether intrahepatic liver stem/progenitor cells comprise true stem cells or progenitor cells (or both) will be approached in some detail.

liver; progenitor cells


Address for reprint requests and other correspondence: Beth Israel Medical Center, Division of Digestive Diseases, 16th St. at 1st Ave., New York, NY 10003 (e-mail: ntheise{at}chpnet.org)




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