HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/1/G165    most recent 00152.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Melgar, S. Articles by Bohlooly-Y, M. Search for Related Content PubMed PubMed Citation Articles by Melgar, S. Articles by Bohlooly-Y, M.

INFLAMMATION/IMMUNITY/MEDIATORS

Mice with experimental colitis show an altered metabolism with decreased metabolic rate

¹Department of Integrative Pharmacology, Gastrointestinal Biology, ²Department of Molecular Pharmacology, and ³AstraZeneca Transgenics and Comparative Genomics Centre, AstraZeneca Research and Development, Mölndal; and ⁴Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Submitted 6 April 2006 ; accepted in final form 5 July 2006

Patients with inflammatory bowel disease (IBD) suffer from body weight loss, malnutrition, and several other metabolic alterations affecting their quality of life. The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. Clinical symptoms and inflammatory markers revealed the presence of an ongoing inflammatory response in the DSS-treated mice. Mice with acute inflammation had decreased body weight, respiratory exchange ratios (RER), food intake, and body fat content. Mice with chronic inflammation had decreased nutrient uptake, body fat content, locomotor activity, metabolic rates, and bone mineral density. Despite this, the body weight, food and water intake, lean mass, and RER of these mice returned to values similar to those in healthy controls. Thus, murine experimental colitis is associated with significant metabolic alterations similar to IBD patients. Our data show that the metabolic responses during acute and chronic inflammation are different, although the metabolic rate is reduced in both phases. These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology.

dual-energy X-ray absorptiometry; dextran sulfate sodium; colon inflammation; respiratory exchange ratio

This article has been cited by other articles:

				L. Harris, P. Senagore, V. B. Young, and L. R. McCabe Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice Am J Physiol Gastrointest Liver Physiol, May 1, 2009; 296(5): G1020 - G1029. [Abstract] [Full Text] [PDF]