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Am J Physiol Gastrointest Liver Physiol 292: G208-G214, 2007. First published August 3, 2006; doi:10.1152/ajpgi.00151.2006 Free Article
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NEUROREGULATION AND MOTILITY

Gastric accommodation and motility are influenced by the barostat device: assessment with magnetic resonance imaging

Ingrid M. de Zwart,2 Jeoffrey J. L. Haans,1 Paul Verbeek,1 Paul H. C. Eilers,3 Albert de Roos,2 and Ad A. M. Masclee1

1Department of Gastroenterology and Hepatology, 2Department of Radiology, and 3Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands

Submitted 6 April 2006 ; accepted in final form 3 August 2006

The barostat is considered the gold standard for evaluation of proximal gastric motility especially for the accommodation response to a meal. The procedure is invasive because it involves the introduction of an intragastric catheter and bag and is not always well tolerated. Moreover, the barostat bag itself may influence motility. Nowadays magnetic resonance imaging (MRI) is able to measure several aspects of gastric motility noninvasively. To evaluate whether the accommodation response of the stomach, observed with the barostat, is present during MRI and whether the barostat interferes with gastric physiology, gastric accommodation, motility, and emptying were studied twice in 14 healthy subjects with MRI using three-dimensional volume scans and two-dimensional dynamic scans once in the presence of a barostat bag and once when the barostat bag was not present. Fasting and postprandial intragastric volumes were significantly higher in the experiment with barostat vs. without barostat (fasting: 350 ± 132 ml vs. 37 ± 21 ml, P < 0.0001; postprandial: 852 ± 126 ml vs. 361 ± 62 ml, P < 0.0001). No significant differences were found in gastric emptying (88 ± 41 vs. 97 ± 40 ml/h, not significant) and contraction frequency between both experiments. The accommodation response observed in the presence of the barostat bag was not observed in the absence of the barostat bag. In conclusion, the presence of an intragastric barostat bag does not interfere with gastric emptying or motility, but the accommodation response measured with the barostat in situ is not observed without the barostat bag in situ. Gastric accommodation is a nonphysiological barostat-induced phenomenon.

gastric motility; meal accommodation; gastric emptying; single photon emission computed tomography; ultrasound


Address for reprint requests and other correspondence: A. A. M. Masclee, Dept. of Gastroenterology-Hepatology, Leiden Univ. Medical Center, Albinusdreef 2, NL-2333 ZA Leiden, The Netherlands (e-mail: a.masclee{at}sint.azm.nl)






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