HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/3/G699    most recent 00517.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Holzer, P. Search for Related Content PubMed PubMed Citation Articles by Holzer, P.

THEMES

Taste Receptors in the Gastrointestinal Tract. V. Acid sensing in the gastrointestinal tract

Research Unit of Translational Neurogastroenterology, Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria

Submitted 6 November 2006 ; accepted in final form 20 November 2006

Luminal acidity is a physiological challenge in the foregut, and acidosis can occur throughout the gastrointestinal tract as a result of inflammation or ischemia. These conditions are surveyed by an elaborate network of acid-governed mechanisms to maintain homeostasis. Deviations from physiological values of extracellular pH are monitored by multiple acid sensors expressed by epithelial cells and sensory neurons. Acid-sensing ion channels are activated by moderate acidification, whereas transient receptor potential ion channels of the vanilloid subtype are gated by severe acidosis. Some ionotropic purinoceptor ion channels and two-pore domain background K⁺ channels are also sensitive to alterations of extracellular pH.

acidosis; acid-induced motor programs; acid-sensing ion channels; gastric acid; hyperalgesia; inflammation; ionotropic purinoceptor ion channels; ischemia; mucosal protection; pain; transient receptor potential ion channels of the vanilloid subtype; two-pore domain potassium channels

This article has been cited by other articles:

				M. Mazzoni, M. Le Gall, S. De Filippi, L. Minieri, P. Trevisi, J. Wolinski, G. Lalatta-Costerbosa, J.-P. Lalles, P. Guilloteau, and P. Bosi Supplemental Sodium Butyrate Stimulates Different Gastric Cells in Weaned Pigs J. Nutr., August 1, 2008; 138(8): 1426 - 1431. [Abstract] [Full Text] [PDF]

				C H Knowles and Q Aziz Visceral hypersensitivity in non-erosive reflux disease Gut, May 1, 2008; 57(5): 674 - 683. [Full Text] [PDF]

				A. N. Reid, R. Pandey, K. Palyada, L. Whitworth, E. Doukhanine, and A. Stintzi Identification of Campylobacter jejuni Genes Contributing to Acid Adaptation by Transcriptional Profiling and Genome-Wide Mutagenesis Appl. Envir. Microbiol., March 1, 2008; 74(5): 1598 - 1612. [Abstract] [Full Text] [PDF]