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THEMES

TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia

Submitted 28 July 2006 ; accepted in final form 6 September 2006

Recent observations suggest that bacterial flagellin may be a target of the seemingly aberrant innate and adaptive immune responses that are associated with Crohn's disease. This article discusses the evidence that supports a role for flagellin in Crohn's disease and considers the potential roles of these responses in the pathophysiology of this disorder.

Toll-like receptor 5; adaptive immunity; epithelial cell