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Am J Physiol Gastrointest Liver Physiol 292: G1465-G1468, 2007. First published December 28, 2006; doi:10.1152/ajpgi.00566.2006
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THEMES

Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease

Benny Hung-Junn Chang1 and Lawrence Chan1,2

1Department of Molecular and Cellular Biology and 2Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas

Submitted 12 December 2006 ; accepted in final form 18 December 2006

ADFP is the major lipid droplet protein present in all cells that accumulate lipids either normally or abnormally. Although discovered about 15 years ago, it was only in the last few years that we began to have a working knowledge of its possible role in lipid droplet homeostasis at the whole organism level. In this perspective, we concentrate on the potential function of ADFP in various tissues. Space limitation has precluded a complete cataloging of all publications on the topic. We instead highlight some of the salient developments in the last few years.

adipose differentiation-related protein; fatty liver; obesity


Address for reprint requests and other correspondence: L. Chan, Division of Diabetes, Endocrinology, and Metabolism, Depts. of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 (e-mail: lchan{at}bcm.tmc.edu)




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