HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/3/G519    most recent 00189.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Black, D. D. Search for Related Content PubMed PubMed Citation Articles by Black, D. D.

THEMES

Development and Physiological Regulation of Intestinal Lipid Absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion

Children's Foundation Research Center of Memphis, Le Bonheur Children's Medical Center, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee

Submitted 30 April 2007 ; accepted in final form 7 May 2007

The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues. The cellular mechanisms involved in enterocyte chylomicron assembly have recently been elucidated, and data on their regulation in the immature gut are beginning to emerge. This review focuses on key proteins involved in chylomicron assembly: apolipoprotein B-48, microsomal triglyceride transfer protein, and apolipoproten A-IV. Recent studies support a role for apolipoprotein A-IV in enhancing chylomicron secretion by promoting production of larger particles. These proteins are regulated in a manner to maximize the lipid absorptive capacity of the newborn intestine.

apolipoprotein A-IV; apolipoprotein B-48; microsomal triglyceride transfer protein; newborn; small intestine

This article has been cited by other articles:

				G. Mailhot, Z. Ravid, S. Barchi, A. Moreau, R. Rabasa-Lhoret, and E. Levy CFTR knockdown stimulates lipid synthesis and transport in intestinal Caco-2/15 cells Am J Physiol Gastrointest Liver Physiol, December 1, 2009; 297(6): G1239 - G1249. [Abstract] [Full Text] [PDF]

				J. Zhu, B. Lee, K. K. Buhman, and J.-X. Cheng A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging J. Lipid Res., June 1, 2009; 50(6): 1080 - 1089. [Abstract] [Full Text] [PDF]

				J. Iqbal and M. M. Hussain Intestinal lipid absorption Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1183 - E1194. [Abstract] [Full Text] [PDF]