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This Article Full Text Full Text (PDF) All Versions of this Article: 293/4/G645    most recent 00299.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mansbach, C. M. Articles by Gorelick, F. Search for Related Content PubMed PubMed Citation Articles by Mansbach, C. M., II Articles by Gorelick, F.

THEMES

Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons

¹Division of Gastroenterology, The University of Tennessee Health Science Center and Veterans Affairs Medical Center, Memphis, Tennessee, and ²Department of Medicine, Veterans Affairs Healthcare Connecticut, and Yale University School of Medicine, New Haven, Connecticut

Submitted 2 July 2007 ; accepted in final form 5 July 2007

Research in dietary fat absorption has developed urgency because of the widely recognized epidemic of obesity in the United States. Despite its clinical importance, many controversies exist over some of the basic aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of families of acyl-CoA synthetase long chains and acyltransferases, a physiological function for liver-fatty acid binding protein, and the characterization of the prechylomicron transport vesicle transporting chylomicrons from the endoplasmic reticulum to the Golgi.

lipid absorption; chylomicrons; transport vesicles; acyl-transferases; lipoproteins

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