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THEMES
1Division of Gastroenterology, The University of Tennessee Health Science Center and Veterans Affairs Medical Center, Memphis, Tennessee, and 2Department of Medicine, Veterans Affairs Healthcare Connecticut, and Yale University School of Medicine, New Haven, Connecticut
Submitted 2 July 2007 ; accepted in final form 5 July 2007
Research in dietary fat absorption has developed urgency because of the widely recognized epidemic of obesity in the United States. Despite its clinical importance, many controversies exist over some of the basic aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of families of acyl-CoA synthetase long chains and acyltransferases, a physiological function for liver-fatty acid binding protein, and the characterization of the prechylomicron transport vesicle transporting chylomicrons from the endoplasmic reticulum to the Golgi.
lipid absorption; chylomicrons; transport vesicles; acyl-transferases; lipoproteins
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