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Am J Physiol Gastrointest Liver Physiol 293: G645-G650, 2007. First published July 12, 2007; doi:10.1152/ajpgi.00299.2007
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Development and Physiological Regulation of Intestinal Lipid Absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons

Charles M. Mansbach, II1 and Fred Gorelick2

1Division of Gastroenterology, The University of Tennessee Health Science Center and Veterans Affairs Medical Center, Memphis, Tennessee, and 2Department of Medicine, Veterans Affairs Healthcare Connecticut, and Yale University School of Medicine, New Haven, Connecticut

Submitted 2 July 2007 ; accepted in final form 5 July 2007

Research in dietary fat absorption has developed urgency because of the widely recognized epidemic of obesity in the United States. Despite its clinical importance, many controversies exist over some of the basic aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of families of acyl-CoA synthetase long chains and acyltransferases, a physiological function for liver-fatty acid binding protein, and the characterization of the prechylomicron transport vesicle transporting chylomicrons from the endoplasmic reticulum to the Golgi.

lipid absorption; chylomicrons; transport vesicles; acyl-transferases; lipoproteins


Address for reprint requests and other correspondence: C. M. Mansbach II, Division of Gastroenterology, The Univ. of Tennessee Health Science Center, 920 Madison Ave., Suite 240, Memphis, TN 38163 (e-mail: cmansbach{at}utmem.edu)






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