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Am J Physiol Gastrointest Liver Physiol 293: G651-G656, 2007. First published July 12, 2007; doi:10.1152/ajpgi.00298.2007
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THEMES

Role of NKT Cells in the Digestive System. I. Invariant NKT cells and liver diseases: is there strength in numbers?

Maureen N. Ajuebor1

1Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center, Shreveport, Louisiana

Submitted 29 June 2007 ; accepted in final form 9 July 2007

Information regarding the functional role of the innate immune T cell, invariant natural killer T (iNKT) cells, in the pathophysiology of liver diseases continues to emerge. Results from animal studies suggest that iNKT cells can have divergent roles by specifically promoting the development of proinflammatory or anti-inflammatory responses in liver diseases. In this themes article, I discuss the critical evidence from animal models that demonstrate a vital role for iNKT cells in the pathophysiology of liver diseases with emphasis on viral, autoimmune, and toxin-induced liver diseases. Furthermore, I discuss the controversial issues (including iNKT cell apoptosis) that typify some of these studies. Finally, I highlight areas that require additional investigation.

invariant natural killer T cells; hepatitis; liver; innate immunity; Th1/Th2 cytokines; apoptosis


Address for reprint requests and other correspondence: Maureen N. Ajuebor, Louisiana State Univ. Health Sciences Center, Dept. of Molecular & Cellular Physiology, 1501 Kings Highway, Shreveport, LA 71130-3932 (e-mail: majueb{at}lsuhsc.edu)




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B. Gao, S. Radaeva, and O. Park
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
J. Leukoc. Biol., September 1, 2009; 86(3): 513 - 528.
[Abstract] [Full Text] [PDF]


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