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THEMES

Role of NKT Cells in the Digestive System. I. Invariant NKT cells and liver diseases: is there strength in numbers?

¹Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center, Shreveport, Louisiana

Submitted 29 June 2007 ; accepted in final form 9 July 2007

Information regarding the functional role of the innate immune T cell, invariant natural killer T (iNKT) cells, in the pathophysiology of liver diseases continues to emerge. Results from animal studies suggest that iNKT cells can have divergent roles by specifically promoting the development of proinflammatory or anti-inflammatory responses in liver diseases. In this themes article, I discuss the critical evidence from animal models that demonstrate a vital role for iNKT cells in the pathophysiology of liver diseases with emphasis on viral, autoimmune, and toxin-induced liver diseases. Furthermore, I discuss the controversial issues (including iNKT cell apoptosis) that typify some of these studies. Finally, I highlight areas that require additional investigation.

invariant natural killer T cells; hepatitis; liver; innate immunity; Th1/Th2 cytokines; apoptosis