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THEMES

The Adventures of Sonic Hedgehog in Development and Repair. IV. Sonic hedgehog processing, secretion, and function in the stomach

Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio

Submitted 23 January 2008 ; accepted in final form 21 February 2008

Sonic hedgehog (Shh) is recognized as one of the main morphogens that regulates cell differentiation during early development of the stomach. In the adult stomach, Shh is expressed and secreted from the acid-producing parietal cells, where it is believed to play an essential role in gastric tissue homeostasis and normal differentiation of the epithelium. The present Themes article focuses on reviewing the literature and controversies surrounding the processing and secretion and the role of Shh in the adult stomach.

parietal cells; pepsinogen; cancer; inflammation; Heliobacter pylori