HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 295/3/G542    most recent 00081.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Lin, W.-Y. Articles by Lee, Y.-H. PubMed PubMed Citation Articles by Lin, W.-Y. Articles by Lee, Y.-H.

HORMONES AND SIGNALING

Hepatocyte nuclear factor-1 regulates glucocorticoid receptor expression to control postnatal body growth

Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

Submitted 17 February 2008 ; accepted in final form 19 June 2008

Hepatocyte nuclear factor 1 (HNF-1) is a homeodomain-containing transcription factor and is important in postnatal growth and development in mice. In the HNF-1-deficient liver, the expressions of a large set of growth hormone (GH)-responsive genes were significantly downregulated. By analyzing various HNF-1 mutant mice, we disclosed a mechanism by which hepatic HNF-1 regulates the expression of GH-responsive genes that are crucial for growth and development. We found that HNF-1 is required for the normal expression of glucocorticoid receptor (GR) specifically in livers. In the liver, GR, together with STAT5, is known to mediate the GH action by transactivating the GH-responsive genes that function in body growth and development. We further demonstrated that HNF-1 modulated GR gene expression by directly transactivating the GR gene promoter via a cryptic regulatory element located 3 bp upstream of the translation start site in exon 2 of the GR gene locus.

transactivation; promoter element