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Am J Physiol Gastrointest Liver Physiol 297: G241-G248, 2009. First published June 11, 2009; doi:10.1152/ajpgi.00138.2009
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REVIEW

Progress and future challenges in stem cell-derived liver technologies

Donna M. Dalgetty,* Claire N. Medine,* John P. Iredale, and David C. Hay

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom

Submitted 9 April 2009 ; accepted in final form 4 June 2009

ABSTRACT

The emergence of regenerative medicine has led to significant advances in the identification and understanding of human stem cells and adult progenitor cells. Both cell populations exhibit plasticity and theoretically offer a potential source of somatic cells in large numbers. Such a resource has an important role to play in the understanding of human development, in modeling human disease and drug toxicity, and in the generation of somatic cells in large numbers for cell-based therapies. Presently, liver transplantation is the only effective treatment for end-stage liver disease. Although this procedure can be carried out with high levels of success, the routine transplant of livers is severely limited by organ donor availability. As a result, attention has focused on the ability to restore liver mass and function by alternative approaches ranging from the bioartificial device to transplantation of human hepatocytes. In this review we will focus on the generation of human hepatic endoderm from different stem/progenitor cell populations with a view to its utility in regenerative medicine.

embryonic stem cell; function; hepatocyte; induced pluripotent stem cell


Address for reprint requests and other correspondence: D. C. Hay, Medical Research Council Centre for Regenerative Medicine, Univ. of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, Scotland, UK (e-mail: davehay{at}talktalk.net)






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