AJP - GI Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 297: G241-G248, 2009. First published June 11, 2009; doi:10.1152/ajpgi.00138.2009
0193-1857/09 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A corrigendum has been published
Right arrow All Versions of this Article:
297/2/G241    most recent
00138.2009v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dalgetty, D. M.
Right arrow Articles by Hay, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dalgetty, D. M.
Right arrow Articles by Hay, D. C.

REVIEW

Progress and future challenges in stem cell-derived liver technologies

Donna M. Dalgetty,* Claire N. Medine,* John P. Iredale, and David C. Hay

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom

Submitted 9 April 2009 ; accepted in final form 4 June 2009

ABSTRACT

The emergence of regenerative medicine has led to significant advances in the identification and understanding of human stem cells and adult progenitor cells. Both cell populations exhibit plasticity and theoretically offer a potential source of somatic cells in large numbers. Such a resource has an important role to play in the understanding of human development, in modeling human disease and drug toxicity, and in the generation of somatic cells in large numbers for cell-based therapies. Presently, liver transplantation is the only effective treatment for end-stage liver disease. Although this procedure can be carried out with high levels of success, the routine transplant of livers is severely limited by organ donor availability. As a result, attention has focused on the ability to restore liver mass and function by alternative approaches ranging from the bioartificial device to transplantation of human hepatocytes. In this review we will focus on the generation of human hepatic endoderm from different stem/progenitor cell populations with a view to its utility in regenerative medicine.

embryonic stem cell; function; hepatocyte; induced pluripotent stem cell


Address for reprint requests and other correspondence: D. C. Hay, Medical Research Council Centre for Regenerative Medicine, Univ. of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, Scotland, UK (e-mail: davehay{at}talktalk.net)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2009 by the American Physiological Society.