AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 297: G1274-G1280, 2009. First published October 1, 2009; doi:10.1152/ajpgi.00214.2009
0193-1857/09 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
297/6/G1274    most recent
ajpgi.00214.2009v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Stevens, J. E.
Right arrow Articles by Jones, K. L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stevens, J. E.
Right arrow Articles by Jones, K. L.

Neuroregulation and Motility

Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects

Julie E. Stevens,1,2 Selena Doran,1 Antonietta Russo,1 Deirdre O'Donovan,1 Christine Feinle-Bisset,1,2 Christopher K. Rayner,1,2 Michael Horowitz,1,2 and Karen L. Jones1,2

1Discipline of Medicine and 2Centre of Clinical Research Excellence, Nutritional Physiology, Interventions and Outcomes, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia

Submitted June 5, 2009 ; accepted in final form September 28, 2009

Gastric emptying (GE) of glucose is regulated closely, not only as a result of inhibitory feedback arising from the small intestine, but also because of the resulting hyperglycemia. Fructose is used widely in the diabetic diet and is known to empty from the stomach slightly faster than glucose but substantially slower than water. The aims of this study were to determine whether intravenous (iv) fructose affects GE and antropyloroduodenal motility and how any effects compare to those induced by iv glucose. Six healthy males (age: 26.7 ± 3.8 yr) underwent concurrent measurements of GE of a solid meal (100 g ground beef labeled with 20 MBq 99mTc-sulfur colloid) and antropyloroduodenal motility on three separate days in randomized order during iv infusion of either fructose (0.5 g/kg), glucose (0.5 g/kg), or isotonic saline for 20 min. GE (scintigraphy), antropyloroduodenal motility (manometry), and blood glucose (glucometer) were measured for 120 min. There was a rise in blood glucose (P < 0.001) after iv glucose (peak 16.4 ± 0.6 mmol/l) but not after fructose or saline. Intravenous glucose and fructose both slowed GE substantially (P < 0.005 for both), without any significant difference between them. Between t = 0 and 30 min, the number of antral pressure waves was less after both glucose and fructose (P < 0.002 for both) than saline, and there were more isolated pyloric pressure waves during iv glucose (P = 0.003) compared with fructose and saline (P = NS for both) infusions. In conclusion, iv fructose slows GE and modulates gastric motility in healthy subjects, and the magnitude of slowing of GE is comparable to that induced by iv glucose.

glucose; glycemia scintigraphy; manometry


Address for reprint requests and other correspondence: K. L. Jones, Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, AUSTRALIA (e-mail: karen.jones{at}adelaide.edu.au).






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2009 by the American Physiological Society.