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Am J Physiol Gastrointest Liver Physiol (October 29, 2009). doi:10.1152/ajpgi.00075.2009
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Research Article

IL-22 is involved in liver regeneration after hepatectomy

Xiaodan Ren1 and Lisa M. Colletti1,*

1University of Michigan Medical School

Submitted 27 February 2009 ; revision received 23 September 2009 ; accepted in final form 20 October 2009

ABSTRACT

Hepatocyte proliferation following partial hepatectomy is an important component of liver regeneration and recent in vitro studies have shown that IL-22 is involved in cellular proliferation in a variety of cell types, including hepatocytes. IL-22 functions through IL-10Rβ and IL-22R{alpha}. The goal of this study was to investigate the potential role of IL-22 in liver regeneration after 70% hepatectomy. Following 70% hepatectomy, done under general anesthesia in mice, serum IL-22 and hepatic IL-22R{alpha} mRNA were significantly increased. While administration of exogenous IL-22 prior to hepatectomy did not increase hepatocyte proliferation, administration of anti-IL-22 antibody before hepatectomy did significantly decreased hepatocyte proliferation. Further, IL-22 treatment prior to 70% hepatectomy induced stat-3 activation; no significant changes were seen in ERK1/2 activation, stat-1 activation or stat-5 activation. IL-22 pretreatment also significantly increased hepatic and serum IL-6 levels. In addition, animals treated with anti-IL-22 antibody expressed less TGF-{alpha}. Conclusions: These data suggest that IL-22 is involved in liver regeneration and this may be due to interaction with IL-6- and TGF-{alpha} cascades.

cytokines; hepatocyte proliferation; interleukin-6; transforming growth factor alpha


* University of Michigan Medical School colletti{at}med.umich.edu






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