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Fig. 3.   Substance P (SP) and carbachol-evoked increases in I_sc were not attenuated until day 7 of the inflammatory response. A, right: substance P (SP) evoked a dose-dependent increase in I_sc (EC₅₀ = ~100 nM) in nonoperated controls. Each point represents the mean ± SE (n = 5). Left, carbachol also evokes a dose-dependent increase in I_sc (EC₁₀₀ = ~100 µM) in nonoperated controls. In the presence of TTX (1 µM), which blocks submucosal secretomotor responses, large responses persisted, suggesting carbachol acted predominantly on the enterocyte (see text). Each point represents the mean ± SE (n = 5 for each point). B: carbachol-evoked (1 µM) I_sc (open bars) in TNBS preparations is also unchanged from sham surgical controls (saline; filled bars) from days 1 to 5 but is significantly attenuated by day 7 (*P < 0.05). Attenuated levels at day 14 also closely approach significance (P = 0.06) C: SP-evoked (100 nM) I_sc (open bars) in TNBS preparations is unchanged from surgical controls (saline) (filled bars) from days 1 to 5 but is significantly attenuated by day 7 (*P < 0.05). This attenuation persists at day 14 and returns to control levels by day 30. Each point represents the mean ± SE (n = 5). I_sc, change in I_sc.

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