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Am J Physiol Gastrointest Liver Physiol (February 28, 2008). doi:10.1152/ajpgi.00031.2008
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Submitted on January 23, 2008
Accepted on February 21, 2008

SONIC HEDGEHOG PROCESSING, SECRETION AND FUNCTION IN THE STOMACH

Yana Zavros1*

1 Molecular and Cellular Physiology, University of Cincinnati College Medicine, Cincinnati, Ohio, United States

* To whom correspondence should be addressed. E-mail: yana.zavros{at}uc.edu.

Sonic Hedgehog (Shh) is recognized as one of the main morphogens that regu-lates cell differentiation during early development of the stomach. In the adult stomach, Shh is expressed and secreted from the acid-producing parietal cells, where it is believed to play an essential role in gastric tissue homeostasis and normal differentiation of the epithelium. The current themes article has focused on reviewing the literature and controversies surrounding the processing and secretion, and the role of Shh in the adult stomach.




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