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Am J Physiol Gastrointest Liver Physiol (December 19, 2001). doi:10.1152/ajpgi.00037.2001
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Articles in PresS, published online ahead of print December 19, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00037.2001
Submitted on January 23, 2001
Accepted on November 25, 2001

ALTERATIONS IN CAPSAICIN-EVOKED ELECTROLYTE TRANSPORT DURING THE EVOLUTION OF GUINEA PIG TNBS-ILEITIS

Paula Miceli, Gerald P Morris, Wallace K MacNaughton, and Stephen J Vanner*

* To whom correspondence should be addressed. E-mail: vanners{at}hdh.kari.net.

The efferent secretomotor activity of capsaicin-sensitive nerves was monitored during the evolution of trinitrobenzene-sulfonic acid (TNBS)-induced ileitis in the guinea pig by recording changes in short circuit current ({Delta}Isc) in response to capsaicin, substance P, and carbachol. Submucosal-mucosal preparations mounted in standard Ussing chambers were studied at times 0, 8 hours, and 1, 3, 5, 7, 14, and 30 days following the intraluminal instillation of TNBS or saline. Maximal {Delta}Isc responses to capsaicin were dramatically attenuated (54%) by 24 hours. By day 7, SP- and TTX-insensitive carbachol-stimulated {Delta}Isc were also significantly reduced. Similar attenuation in capsaicin and carbachol responses was observed in jejunal tissue 20 cm proximal to the inflamed site at day 7. These studies demonstrate that efferent secretomotor function of capsaicin-sensitive nerves is maintained early in TNBS-ileitis but significantly reduced by 24 hours. By 7 days, defects in enterocyte secretory function at inflamed and non-inflamed sites also occurred, an effect which may be mediated by circulating cytokines.




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