AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol (February 27, 2002). doi:10.1152/ajpgi.00043.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/G919    most recent
00043.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schemann, M.
Right arrow Articles by Neunlist, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Schemann, M.
Right arrow Articles by Neunlist, M.

Articles in PresS, published online ahead of print February 27, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00043.2002
Submitted on February 1, 2002
Accepted on February 7, 2002

Imaging and the Gastrointestinal Tract - Mapping the Human Enteric Nervous System

Michael Schemann1*, Klaus Michel1, Saskia Peters1, Stephan C Bischoff2, and Michel Neunlist1

1 Department of Physiology, School of Veterinary Medicine, Hannover, Germany
2 Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany

* To whom correspondence should be addressed. E-mail: Michael.Schemann{at}tiho-hannover.de.

Monitoring membrane potentials by multi-site optical recording techniques using voltage sensitive dyes is ideal for direct analysis of network signaling. We applied this technology to monitor fast and slow excitability changes in the enteric nervous system and this in hundreds of neurons simultaneously at cellular and subcellular resolution. This imaging technique presents a powerful tool to study activity patterns in enteric pathways and to assess differential activation of nerves in the gut to a number of stimuli which modulate neuronal activity directly or through synaptic mechanisms. The optical mapping made it possible to record from tissues like human enteric nerves which were up to now inaccessible by other techniques.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. E. Wunderlich, B. J. Needleman, Z. Chen, J. G. Yu, Y. Wang, I. Grants, D. J. Mikami, W. S. Melvin, H. J. Cooke, and F. L. Christofi
Dual purinergic synaptic transmission in the human enteric nervous system
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G554 - G566.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. Breunig, K. Michel, F. Zeller, S. Seidl, C. W. H. v. Weyhern, and M. Schemann
Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
J. Physiol., September 1, 2007; 583(2): 731 - 742.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
A. L. Obaid, M. E. Nelson, J. Lindstrom, and B. M. Salzberg
Optical studies of nicotinic acetylcholine receptor subtypes in the guinea-pig enteric nervous system
J. Exp. Biol., August 1, 2005; 208(15): 2981 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Neunlist, J. Barouk, K. Michel, I. Just, T. Oreshkova, M. Schemann, and J. P. Galmiche
Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1{beta}-dependent pathway
Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G1049 - G1055.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1979 by the American Physiological Society.